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| 男性强直性脊柱炎患者骨密度与血尿酸水平相关性研究 |
| Correlation between bone mineral density and serum uric acid level in male patients with ankylosing spondylitis |
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| DOI：10.3969/j.issn.1006.7108.2020.04.007 |
| 中文关键词: 强直性脊柱炎 血尿酸 骨密度 |
| 英文关键词:ankylosing spondylitis serum uric acid bone mineral density |
| 基金项目:国家自然科学基金青年项目（81403378）；北京市自然科学基金（7182148）；中日友好医院青年科技英才培养计划（2014-QNYC-B-02） |
| 作者 | 单位 | | 孙文婷1,2 朱峰1,2 郑丹妮1,2 李艳萍1,2 杨爱娟1,2 胡丽芳1,2 穆闻君1,2 张楠2,3 陶庆文2,3 阎小萍2,3 孔维萍2,3* | 1.北京中医药大学，北京 100029
2.中日友好医院中医风湿病科，北京 100029；
3.免疫炎性疾病北京市重点实验室，北京 100029 |
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| 中文摘要: |
| 目的 分析强直性脊柱炎（ankylosing spondylitis，AS）男性患者骨密度（bone mineral density，BMD）与血尿酸（serum uric acid，SUA）的相关关系。方法 回顾性分析2013年9月到2018年9月在中日友好医院确诊的143名男性AS患者，按腰椎、股骨颈、股骨粗隆BMD水平各分为正常骨量组和骨量减少组。比较两组间患者临床基本资料、疾病活动程度指标等的差异；使用多元回归分析评估SUA水平与男性AS患者各部位BMD的关系；使用Logistic回归模型预测SUA与各部位BMD之间的风险概率；构建列线图预测男性AS患者腰椎及股骨粗隆发生骨量减少的风险。结果 两组间比较结果显示，身高、腰椎、股骨颈、股骨粗隆BMD比较差异均有统计学意义（均P<0.05）。多元线性回归分析提示SUA水平与腰椎、股骨粗隆的BMD呈正相关。Logistic回归分析结果提示，SUA每降低78 mmol/L发生腰椎和股骨粗隆骨量减少的风险分别升高18%和17%。通过构建的列线图可预测男性AS患者发生腰椎及股骨粗隆骨量减少的风险。 结论 SUA水平低可能会增加男性AS患者腰椎和股骨粗隆骨量减少的风险，SUA具有反映男性AS患者骨量减少风险的潜力。 |
| 英文摘要: |
| Objective To analyze the relationship between bone mineral density (BMD) and serum uric acid (SUA) in male patients with ankylosing spondylitis (AS). Methods A retrospective analysis was made in 143 male AS patients diagnosed from September 2013 to September 2018 in the China-Japan Friendship Hospital. According to the level of BMD of lumbar spine, femoral neck and femoral trochanter, patients were divided into the normal bone mass and low bone mass group. The clinical basic data, disease activity index and other information were compared between the two groups. The relationship between SUA level and BMD of various sites was evaluated by multiple regression analysis. Logistic regression model was used to predict the risk probability between SUA and BMD of various sites. Prediction nomograms were constructed to predict the risk of low bone mass at lumbar spine and femoral trochanter in male AS patients. Results Comparison analysis between the two groups showed that there were significant differences in height and the level of BMD at lumbar spine, femoral neck and femoral trochanter (all P<0.05). Multiple regression analysis suggested that SUA levels were positively associated with BMD of lumbar spine and femoral trochanter. Logistic regression analysis showed that the risk of a reduction in lumbar spine and femoral trochanteric bone mass increased by 18% and 17% for each 78 mmol/L reduction in SUA. The risk of lumbar spine and femoral trochanter low bone mass in male AS patients could be predicted according to the prediction nomograms. Conclusion Low SUA level may increase the risk of low bone mass at lumbar spine and femoral trochanter in male AS patients. SUA has the potential to reflect the risk of low bone mass in male AS patients. |
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