中西医治疗糖尿病性骨质疏松的临床观察
Clinical observation on the treatment of diabetic osteoporosis with traditional Chinese medicine and western medicine
  
DOI:10.3969/j.issn.1006.7108.2020.04.015
中文关键词:  糖尿病  骨质疏松  中医  辨证施治  临床效果
英文关键词:diabetes  osteoporosis  traditional Chinese medical science  syndrome differentiation and treatment  clinical effect
基金项目:
作者单位
苏风兵* 厦门市第五医院骨科 福建 厦门 361101 
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中文摘要:
      目的 分析探讨中医证型辨证施治糖尿病性骨质疏松的临床效果。方法 选取2016年11月至2017年11月期间在厦门市第五医院住院治疗的72例糖尿病性骨质疏松患者,随机分为对照组和试验组,两组患者均在控制血脂、血压、血糖等基础上进行抗骨质疏松治疗。其中对照组患者联合使用活性维生素D和钙剂进行治疗,对于骨痛较为明显的患者则采用降钙素进行治疗;试验组患者在对照组患者的治疗基础上加用中药,其中对于脾胃气虚型患者以补中益气汤合六君子汤加减治疗,肝肾不足型患者以右归丸合左归丸加减治疗,对于骨痛较为明显的患者则加用姜黄、延胡索、川芎进行治疗。分别检测两组患者治疗前及治疗8周后的临床疗效,记录两组患者的骨代谢相关生化指标和骨密度以及糖尿病控制指标,分析两组患者的生活质量评分以及预后。结果 试验组患者的总有效率为88.89 %,显著高于对照组患者的75.00 %(χ2 7.398,P 0.05)。两组患者治疗前的糖尿病控制指标并无明显差异(P均 0.05);经过治疗后两组患者的糖尿病控制指标均显著优于本组治疗前(P均 0.05),但是两组患者治疗后的糖尿病控制指标并无明显差异(P均 0.05)。两组患者治疗前的骨密度以及骨代谢相关生化指标并无明显差异(P均 0.05);经过治疗后两组患者的骨密度情况均显著优于本组治疗前,并且试验组患者治疗后的骨密度显著优于同期对照组患者(P均 0.05);经过治疗后试验组患者的骨代谢相关生化指标均显著优于同期对照组患者(P均 0.05)。经过治疗后试验组患者的生活质量评分为(68.38 15.33)分,显著优于对照组患者的(55.38 14.39)分(t 3.849,P 0.05);试验组患者的初次骨折率和症状复发率、再次骨折率分别为8.33 %、13.89 %、2.78 %,分别低于对照组患者的27.78 % 、36.11 %和19.44 %(χ2 4.853,χ2 4.938,χ2 5.039, P均 0.05)。结论 对于糖尿病性骨质疏松患者而言,在采用传统的西医常规治疗基础上联合使用中医辨证施治能够有效改善患者的治疗效果和预后,值得在临床上加以推广运用。
英文摘要:
      Objective To analyze the clinical effect of dialectical treatment of diabetic osteoporosis with TCM syndrome. Methods 72 cases of diabetic patients with osteoporosis admitted during the period of November 2016 to November 2017 were selected, and according to random number table method all patients were randomly divided into two groups, control group and test group. The two groups of patients had blood lipids, blood pressure and blood glucose under control and received anti-osteoporosis treatment. The control group patients received active vitamin D and calcium treatment, and patients with evident bone pain also received calcitonin treatment. Experimental group patients received the same treatment as patients in the control group and also received treatment on the basis of traditional Chinese medicine, including for spleen deficiency type patient to make up for in yiqi decoction and six gentlemen tonga subtraction treatment, liver and kidney deficiency pills for patients with right or left to add and subtract treatment, and in patients with evident bone pain turmeric, rhizoma corydalis and rhizoma ligustici wallichii were added for treatment. The clinical efficacy in the two groups of patients before treatment and 8 weeks after treatment were tested, and the biochemical indexes related to bone metabolism, bone density and diabetes control indexes in the two groups were recorded. The quality of life scores and prognosis of the two groups of patients were analyzed. Results The total effective rate of the experimental group was 88.89%, significantly higher than that of the control group (75.00%) (χ2=7.398, P < 0.05). There was no significant difference in diabetes control indexes between the two groups before treatment (all P>0.05). After treatment, the diabetes control indexes of the two groups were significantly better than those before treatment (all P < 0.05), but there was no significant difference in diabetes control indexes between the two groups after treatment (all P>0.05). Before treatment, there were no significant differences in BMD and biochemical indexes related to bone metabolism between the two groups (all P > 0.05). After treatment, the BMD of the two groups was significantly better than that before treatment, and the BMD of the experimental group was significantly better than that of the control group (all P < 0.05). After treatment, the biochemical indexes related to bone metabolism in the experimental group were significantly better than those in the control group (all P<0.05). After treatment, the quality of life score of the experimental group was (68.38±15.33), which was significantly better than that of the control group (55.38±14.39) (t=3.849, P<0.05). The primary fracture rate, symptom recurrence rate and secondary fracture rate in the experimental group were 8.33%, 13.89% and 2.78%, respectively, lower than those in the control group of 27.78%, 36.11% and 19.44% (χ2=4.853, χ2=4.938, χ2=5.039, all P<0.05). Conclusion For the patients with diabetic osteoporosis, the combination of traditional western medicine and traditional Chinese medicine could effectively improve the therapeutic effect and prognosis of the patients, and greatly improve the quality of life of the patients. It is worth popularizing in clinical application.
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