| Objective To analyze and study the correlations of serum bone metabolic markers in osteoporosis patients in Xi'an. Methods 295 cases of primary osteoporosis diagnosed in Honghui Hospital from April 2018 to March 2019 were examined for serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), vitamins D, parathyroid hormone (PTH), type I procollagen N-terminal peptide (P1NP) and β-collagen specific sequences (β-Cross). R statistical language was used for statistical and Pearson correlation analysis. Results Serum Ca and P levels were in the normal range in most patients with osteoporosis; ALP levels were elevated in 20-30% of patients; the vast majority of patients were vitamin D deficient/insufficient; PTH abnormality were mainly elevated PTH and a few female patients had lower PTH; P1NP and β-Cross were in the normal range in most premenopausal women, elevated in a small number of premenopausal women and one-third of men, decreased in a small number of postmenopausal women and increased in a small number of postmenopausal women. In female patients, serum ALP and P1NP, ALP and PTH, vitamin D and β-Cross were positively correlated (P<0.05); serum Ca and β-Cross, P and ALP, P and β-Cross, P and PTH, ALP and vitamin D, ALP and β-Cross, vitamin D and P1NP, vitamin D and PTH, and P1NP and β-Cross were negatively correlated (P<0.05). In male patients, serum vitamin D and β-Cross were positively correlated (P<0.05); serum Ca and PTH, ALP and vitamin D, vitamin D and P1NP, vitamin D and PTH, and P1NP and β-Cross were negatively correlated (P<0.05). Conclusion Vitamin D deficiency/insufficiency is very serious in patients with osteoporosis, understanding the correlation between bone metabolic markers helps to better understand the mechanism of abnormal bone metabolism in osteoporosis. |