| Objective Osteoporosis can lead to fragility fractures, which seriously affect the quality of life of patients. The cause of osteoporosis is complex and not fully understood. Some studies have suggested that osteoporosis may be related to Helicobacter pylori infection, but there are many controversies. Therefore, in this study, we analyzed the detection results of Helicobacter pylori infection and bone turnover markers in the physical examination population in Chengdu, and explored the correlation between Helicobacter pylori (HP) infection and bone turnover markers. Methods The study included 1484 healthy individuals, including 854 males, aged 20-87 years, and 630 females, aged 24-81 years, divided into HP (–) male group, HP (+) male group, HP (–) female group and HP (+) female group. The levels of serum total N-terminal procollagen I propeptides (TPINP), C-terminal telopeptides of type I collagen (β-CTx) and N end of osteocalcin (N-MID) were detected by electrochemiluminescence method, and serum HP antibody was detected by colloidal gold method. Statistical analysis was performed using SPSS 19.0 software. Results The HP infection rate in the physical examination population in Chengdu was as high as 60%-61.5%, and there was no gender difference (P>0.05). The bone formation markers TPINP and N-MID were lower in males than females, but the analysis of variance showed that the difference between genders was not statistically significant (P>0.05). The bone resorption marker β-CTX was higher in males than in females, and the difference was statistically significant (P<0.05). HP infection did not have a significant effect on bone turnover markers in men or women (P>0.05).Conclusion There may be no correlation between Helicobacter pylori infection and osteoporosis in the population. However, the infection rate of Helicobacter pylori in Chengdu is high, and it is necessary to pay attention to its impact on people's health. |