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| FRAX评分在中老年人骨质疏松性骨折风险评估中的研究进展 |
| Advances in the assessment of the risk of osteoporosis fractures in middle-aged and elderly people with the application of FRAX tools |
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| DOI：10.3969/j.issn.1006.7108.2020.04.022 |
| 中文关键词: FRAX 中老年人 骨质疏松 骨折风险 |
| 英文关键词:FRAX middle-aged and elderly people osteoporosis fracture risk |
| 基金项目:广西自然科学基金课题《调控MPS1蛋白激酶联合紫杉醇对骨肉瘤抑制作用及其分子机制研究》(2018JJA140238) ; 广西自然科学基金课题《靶向DKK-1/β-catenin信号通路在酒精性股骨头坏死发病中的作用机制的研究》(2018JJA140251) |
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| 中文摘要: |
| 骨质疏松症( osteoporosis)是一种以骨密度降低、骨小梁及其他组织结构损坏, 造成骨脆性以及骨折风险增加为特征的全身性骨病。FRAX评分是2008年世界卫生组织推荐的骨折风险预测简易诊断工具，可用于计算10年发生髋部骨折及任何重要的骨质疏松性骨折的发生概率。目前FRAX评分的应用才刚刚起步，评价标准还不完善，使用过程存在一定的局限性。但是长远来看，FRAX评分在骨质疏松性骨折预测方面应用前景广阔，将会成为预防骨质疏松性骨折的有力工具。本文将近年来FRAX评分的应用以及研究进展进行综述。以期在骨质疏松性骨折预防、管理、诊断和治疗方面提供新思路、新视角。 |
| 英文摘要: |
| Osteoporosis is a systemic osteopathy characterized by decreased bone density, trabecular and other structural damage, resulting in brittle bone and increased risk of fracture. FRAX is a simple tool for fracture risk prediction recommended by the World Health Organization in 2008. It can be used to calculate the incidence of hip fractures and any significant osteoporosis fractures in 10 years. At present, the application of FRAX tools has just started. The evaluation standards are not perfect. The use process has some limitations. However, in the long run, the application of FRAX tool in the prediction of osteoporosis fracture is promising, and it will become a powerful tool for the prevention of osteoporosis fracture. This paper reviews the application and research progress of FRAX tools in recent years, in order to provide new ideas and new perspectives in the prevention, management, diagnosis, and treatment of osteoporotic fractures. |
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