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| 骨质疏松症的治疗及柚皮苷抗骨质疏松的研究进展 |
| Treatment of osteoporosis and research progress of naringin |
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| DOI：10.3969/j.issn.1006.7108.2020.04.029 |
| 中文关键词: 骨质疏松症 治疗方法 中药 柚皮苷 |
| 英文关键词:osteoporosis treatment Chinese Traditional Medicine naringin |
| 基金项目:国家自然科学基金面上项目（81871777） |
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| 中文摘要: |
| 骨质疏松症是一种常见的代谢性疾病，典型的病理改变是全身骨量降低以及骨微结构的退化和破坏，骨质疏松性骨折是其严重的并发症。随着人口老龄化进展，骨质疏松症，尤其是最常见的绝经后骨质疏松，给全球公共卫生事业带来极大的经济负担，同时也严重影响了患者自身的生活质量。当前普遍认为治疗骨质疏松的关键在于恢复机体内骨代谢的动态平衡，而细胞之间的信号通路是研究的关键。随着新的信号通路不断出现，以其为作用靶点的新型药物也层出不穷，本文初步综述了近年来骨质疏松症的流行病学特点、目前的主要诊断技术、经典药物及新型药物的作用机制，以及从中药骨碎补中提取的单体化合物柚皮苷治疗骨质疏松症的研究进展。 |
| 英文摘要: |
| Osteoporosis is a common metabolic disease characterised by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility. With an ageing population, osteoporosis, especially the most common postmenopausal osteoporosis has brought great economic burden to the global public health, and also seriously affects the quality of life of patients. It is generally believed that the key to the treatment of osteoporosis is to restore the dynamic balance of bone metabolism, and the signal pathway between cells has become a key to research. With the emergence of new signaling pathways, new types of drugs targeting them are also emerging. This paper reviews the epidemiology, current main diagnostic technologies, mechanism of action of classical drugs and new drugs, and the research progress of naringin extracted from Rhizoma Drynariae for the treatment of osteoporosis. |
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