| Objective To evaluate the risk factors of sarcopenia in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM) for the prevention and treatment of sarcopenia. Methods Data of 289 middle-aged and elderly patients with T2DM in the Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University from May to November 2018 were collected. Fifty-seven healthy people during the same period were selected as the control group. The difference of general data, biochemistry, HbA1c, muscle strength, and the detection rate of sarcopenia between the two groups were compared. Pearson correlation analysis and Logistic regression analysis were used to analyze the risk factors of sarcopenia. Results The detection rate of sarcopenia in the T2DM group (22.83%) was higher than that in the normal control group (12.28%, P＜0.05). In T2DM group, skeletal muscle content was positively correlated with body weight, BMI, bone mineral density of the total hip, abdominal fat area, and 25(OH)D3 content, but was negatively correlated with fasting blood glucose and diabetes duration. Low BMI, low 25(OH)D3, low total hip bone mineral density, and long course of diabetes were risk factors for sarcopenia. Conclusion T2DM patients are risk population of sarcopenia. Intervention against the risk factors of sarcopenia may reduce the occurrence of falls, fractures, disabilities, and fatal events in T2DM patients. |