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| 新疆2型糖尿病绝经后女性LRP5rs41494349、rs2306862位点基因多态性及突变与骨代谢的关系 |
| Relationship between bone metabolism and genetic polymorphisms of LRP5 gene rs41494349 and rs2306862 in postmenopausal women with type 2 diabetes mellitus in Xinjiang |
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| DOI：10.3969/j.issn.1006-7108.2020.05.005 |
| 中文关键词: 低密度脂蛋白受体 基因多态性 2 型糖尿病 骨质疏松 骨密度 |
| 英文关键词:low density lipoprotein receptor gene poly-morphism type 2 diabetes mellitus osteoporosis bone mineral density |
| 基金项目:区域创新引导计划（2018BB040）；兵团中青年科技创新领军人才专项（2015BC001） |
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| 中文摘要: |
| 目的 探讨2型糖尿病(type 2 diabetes mellitus，T2DM）绝经后女性LRP5rs41494349、rs2306862位点基因多态性及突变与骨代谢的关系。方法 收集新疆绝经后汉族女性资料，根据血糖及骨密度（bone mineral density，BMD）分为4组：糖耐量正常伴骨量正常组（A组）、T2DM伴骨量正常组（B组）、糖耐量正常伴骨量异常组（C组）、T2DM伴骨量异常组（D组）。检测各临床指标，测定LRP5rs41494349、rs2306862位点基因型。结果 ①与A组相比，B组、D组FPG、HbA1c%升高，C组、D组TG、BMD(L1～4)、BMD(股骨颈)降低（P＜0.05）。②rs2306862位点，突变型（CT/TT）与野生型（CC）相比，B组P升高，D组BMD(L1～4)、P降低（P＜0.05）；rs41494349位点，突变型（AG/GG）与野生型（AA）相比，D组的BMD(L1～4)降低（P＜0.05）。③多元线性回归分析显示，绝经年限、体质量指数是BMD（L1～4）及BMD（股骨颈）的影响因素，TG是BMD（L1～4）的影响因素，两位点的多态性是BMD（股骨颈）的影响因素。结论 LRP5rs41494339、rs2306862位点基因多态性及突变通过影响BMD及骨代谢指标，可能参与了绝经后女性的T2DM合并骨质疏松的发生和发展。 |
| 英文摘要: |
| Objective To investigate the relationship between polymorphism and mutation of LRP5 rs41494349 and rs2306862 locus gene and bone mineral density (BMD) in postmenopausal women with type 2 diabetes (T2DM). Methods The data of postmenopausal Han women in Xinjiang were collected. According to the results of blood glucose and BMD, women were divided into 4 groups: normal glucose tolerance with normal bone mass group (group A), T2DM with normal bone mass group (group B), normal glucose tolerance with abnormal bone mass group (group C), and T2DM with abnormal bone mass group (group D). The clinical indexes and LRP5 rs41494349 and rs2306862 locus gene polymorphism were measured. Results 1) Compared to those in group A, the levels of FPG and HbA1c% in group B and D increased. The levels of TG, BMD (L1-4), and BMD (femoral neck) in group C and D reduced. 2) Mutant (CT/TT) compared with wild-type (CC) in rs2306862 locus: P increased in group B, and BMD (L1-4) and P decreased in group D (P<0.05). Mutant (AG/GG) compared with wild-type (AA) in rs41494349 locus: BMD (L1-4) in group D decreased. 3) Multivariate linear regression analysis showed that menopause years and BMI were the influential factors of BMD (L1-4) and BMD (femoral neck). TG was the influential factor of BMD (femoral neck). Rs41494339 and rs2306862 locus in LRP5 gene polymorphism were the influential factors of BMD (femoral neck). Conclusion LRP5rs41494339 and rs2306862 locus gene polymorphisms and mutations may be involved in the occurrence and development of OP by affecting BMD and bone metabolism markers in postmenopausal women with T2DM. |
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