| Objective Using the Fracture Risk Assessment Tool (FRAX), to calculate the risk of osteoporotic fracture and to explore the intrinsic relationship between fracture risk and visceral fat mass in 40-50-years-old perimenopausal women. Methods Questionnaire data of 334 perimenopausal women, including age, weight, smoking and alcohol history, previous fracture history, hormone application, etc., from March 2017 to March 2018, were analyzed. Quantitative indexes of bone mineral density (BMD) and visceral fat were obtained with dual energy X-ray scanning. Fracture risk was calculated using FRAX software. The correlation between BMD and visceral fat was analyzed. Results BMD decreased and fracture risk increased gradually with age in perimenopausal women. Visceral fat was negatively correlated with BMD (r=-0.35, P<0.05), but was positively correlated with fracture risk (r=0.58, P<0.05). Conclusion FRAX accurately reflects the risk of fracture in perimenopausal women and it is helpful for early clinical intervention. Visceral fat is one of the pathogenic factors leading to osteoporotic fracture. |