| Objective To evaluate the efficacy of Liuwei Dihuang pill on the treatment of postmenopausal osteoporosis (PMOP). Methods CNKI, CBM, VIP, WanFang, PubMed, Embase, and Cochrane library were systematically retrieved and the included studies were evaluated for the methodological quality. Meta-analysis was used with Review Manager 5.3 software for data analysis. A total of 12 literatures and 14 studies were included. Results Meta-analysis showed that Liuwei Dihuang pill + conventional treatment regimen was effective in the treatment of postmenopausal osteoporosis [OR=1.22, 95%CI (1.13-1.32), P<0.00001]. The pain reduction was better [MD=-0.50, 95% CI (-0.77-0.22), P=0.0004]. The improvement effect on hip bone mineral density was better than that of conventional Western medicine group [MD= 0.55, 95% CI (0.26 - 0.84), P= 0.0002]. However, the improvement of lumbar vertebra density [MD= 0.05, 95% CI (0. 03~0. 07), P<0.0001] by using Liuwei Dihuang pill alone or combined with a single routine intervention was better than that of conventional Western medicine. Liuwei Dihuang pill alone had certain clinical advantages in improving radial bone mineral density [MD=0.02, 95% CI (0.02-0.003), P<0.00001], ulna bone mineral density [MD=0.02, 95% CI (0.01-0.03), P<0.0001]. Conclusion Liuwei Dihuang pill is effective in improving bone mineral density of the hip, the lumbar vertebra, the ulna, and the radius. It improves the efficacy and relieves the pain of PMOP. However, there is insufficient evidence to improve femoral neck density, which may be affected by various factors. At the same time, Liuwei Dihuang pill has an enhanced effect in combination with conventional treatment. Whether the combination of multiple drugs is effective remains to be studied. |