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| 骨质疏松症治疗中维生素D的最佳水平及补充剂量的研究进展 |
| Research progress on the optimal level and supplementary dosage of vitamin D in the treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2020.05.021 |
| 中文关键词: 维生素D 甲状旁腺激素 骨密度 骨折 骨质疏松 |
| 英文关键词:vitamin D parathyroid hormone bone mineral density fracture osteoporosis |
| 基金项目:国家自然科学基金面上项目（81771953） |
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| 中文摘要: |
| 人们普遍认为维生素D（vitamin D，VD）是骨骼系统中的积极调节因子。近年来，骨质疏松症发病率的增加，VD不足及缺乏现象明显，国内外越来越多研究发现骨密度与VD状态之间存在不一致表现，高水平VD状态对提高骨密度及降低骨折风险并没有起到积极作用，VD最佳水平和在骨质疏松症治疗时如何补充VD仍有争议。笔者综述了近年来的研究成果，进一步探讨VD最佳水平、高水平VD的补充对骨密度及骨折的影响，并提出目标25-羟维生素D [25-hydroxyvitamin D，25(OH)D]浓度为20 ng/mL（50 nmol/L），每日VD补充剂量为400～800 IU，超过这一水平增加VD补充剂量是不必要的，甚至可能存在潜在危险。 |
| 英文摘要: |
| It is widely believed that vitamin D (VD) is a positive regulator in the skeletal system. Recently, with the increase of osteoporosis and vitamin D deficiency, more and more national and international studies have found that there is an inconsistency between bone mineral density (BMD) and VD. Studies have also confirmed that high level of vitamin D does not play a positive role in increasing BMD and reducing fracture risk, and the debate about optimal level of VD and how to supplement it in the treatment of osteoporosis have been continued. The paper reviews recent research results, and further explores optimal level of VD and the effects of high level of supplements on BMD and fracture. It is suggested that the target concentration of 25-hydroxyvitamin D [25(OH)D)] is 20 ng/mL (50 nmol/L) and the daily supplement dose of VD is 400-800 IU. Higher dose is unnecessary and may be potentially dangerous. |
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