| Abnormal calcium metabolism exists in both urinary tract stone and osteoporosis patients, and the incidences are high, leading to serious impacts on the quality of life. Studies have shown that there is a certain correlation between them. Hypercalciuria due to increase of bone resorption may be the key bridge between the pathogenesis of the two. In the study of genetic factors, many related genes are found, mainly including ADCY10 gene, CYP24A1 gene, CaSR, and CLDN14 gene. However, the studies of gene variations result in different conclusions, and the specific mechanism remains to be further studied. Estrogen deficiency through bone loss and reduced expression of TRPV5 results in high calcium urine and low bone mass, leading to urolithiasis and osteoporosis. High protein, high sodium, and low calcium intake and other dietary factors also affect the development of both diseases. This paper reviews the research progress of the correlation between the two disorders. |