中国骨质疏松杂志

不同加力时间下静止期牙周病大鼠牙槽骨骨微结构的变化

Changes in alveolar bone microstructure of the animal model of quiescent periodontitis in different afterburning time

DOI：10.3969/j.issn.1006-7108.2020.06.008

中文关键词: 牙槽骨骨质疏松骨微结构牙周病加力

英文关键词:alveolar bone osteoporosis bone microstructure periodontal disease afterburner

基金项目:陕西省卫生计生科研基金扶植项目（2016D022）；西安医学院校级配套基金项目（2017PT19）

作者	单位
周芳1* 赵常红2 李子夏1 曾辉1 黄硕1	1. 西安医学院口腔医学院，陕西西安 710075 2. 西北师范大学体育学院，甘肃兰州 730030

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中文摘要:

目的建立静止期牙周病动物模型，观察不同加力时间下其牙槽骨骨微结构的变化。方法选取156只28周龄SD雄性大鼠，随机分为对照组（50只）和实验组（106只），实验组建立静止期牙周病动物模型，再随机分为牙周治疗组和牙周+正畸治疗组（各50只），对牙周+正畸治疗组动物模型上颌右侧第一磨牙加力，力值为50 g。各组于加力后0、7、14、21、28 d各处死 10 只动物，取材，行Micro-CT检察。结果 ①加力0、7、14、21、28 d，实验组动物模型右侧上颌第一磨牙牙槽骨骨密度（bone mineral density, BMD）、骨体积分数（BV/TV）、骨小梁厚度（Tb·Th）均较对照组降低，骨小梁数量（Tb·N）、骨小梁分离距离（Tb·Sp）均较对照组升高;②相较牙周治疗组，加力14 d时牙周+正畸治疗组动物模型右侧上颌第一磨牙牙槽骨BMD、BV/TV、Tb·Th降低，Tb·N、Tb·Sp升高；加力28 d时，BV/TV升高，Tb·N、Tb·Sp降低;③加力14 d，牙周+正畸治疗组动物模型右侧上颌第一磨牙牙槽骨BMD、BV/TV、Tb·Th降至最低，Tb·N、Tb·Sp升至最高，但至28 d时各项指标已恢复至未加力时状态。结论 ①静止期牙周病动物模型牙槽骨骨质疏松且对力学刺激的反应变缓慢;②突然受力后静止期牙周病动物模型牙槽骨以吸收为主，但随着加力装置力量的减弱和力值的稳定，牙槽骨可逐渐恢复到加力前的状况;③较小的力值刺激有利于静止期牙周病动物模型牙槽骨的修复。

英文摘要:

Objective Established the animal model of quiescent periodontitis and observed the changes of alveolar bone microstructure in different afterburning time.Methods 156 cases SD rats of 28 weeks old were randomly divided into control group (50) and experimental group (106).The experimental group were established animals model of quiescent periodontitis, and were randomly divided into periodontal treatment group (50) and periodontal group with orthodontic treatment (50).The first molar of the right maxillary of latter was applied with a force of 50g.Ten rats were sacrificed and wasobserved by micro-ct at 0 day,7 days,14 days,21 days and 28 days.Results ①For the first molar of the right maxillary in the animal model of experimental group,the alveolar bone mineral density (BMD),bone volume fraction (BV/TV) and trabecular thickness(Tb·Th) were lower,and the number of trabecular bone (Tb·N),trabecular separation distance (Tb·Sp) were higher than those of the control group at 0 day,7 days,14 days,21 days and 28 days;②Compared with periodontal treatment group,BMD,BV/TV and Tb·Th of periodontal group with orthodontic treatment were lower, while Tb·N and Tb·Sp were higher at the 14 days,BV/TV were higher and Tb·N and Tb·Sp were lower at the 28 days;③At 14 days,for the first molar of the right maxillary in periodontal group with orthodontic treatment,BMD,BV/TV and Tb·Th were decreased to the lowest level,while Tb·N and Tb·Sp were increased to the highest level.However,all the indicators had been repaired to the state of unstressed at 28 days.Conclusion ①The alveolar bone of animal models of quiescent periodontitis were osteoporotic,which had a slowed?response?to?mechanical stimulation;②In the animal model of quiescent periodontitis, alveolar bone absorption was the main factor after sudden stress,but as the force weakened and the force value stabilized, the alveolar bone returned to the state before the afterloading gradually;③Small force stimulation was beneficial to the repair of alveolar bone in animal models of quiescent periodontitis.

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