中国骨质疏松杂志

分段低强度跑步与持续中强度跑步对糖尿病性骨质疏松大鼠骨密度、胰岛素抵抗的影响研究

Effects of segmental low-intensity running and continuous medium-intensity running on bone mineral density and insulin resistance in diabetic osteoporosis rats

DOI：10.3969/j.issn.1006-7108.2020.06.011

中文关键词: 糖尿病性骨质疏松运动方式跑步

英文关键词:diabetic osteoporosis exercise mode running

基金项目:重庆市体育局科研项目（B2017019）

作者	单位
李秀焕1* 李国泰2	1.重庆三峡医药高等专科学校公共基础部体育教学部，重庆万州 404020 2.重庆大学体育学院，重庆 400044

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中文摘要:

目的论证接近一般生活态运动模式的分段多次低强度有氧运动方案作为糖尿病性骨质疏松（diabetic osteoporosis，DOP）患者运动处方的可行性。方法采用随机对照动物实验，对100只大鼠进行饮食控制，每天喂食正常饲料5次。第4~10周选取75只大鼠进行DOP造模。第11周对DOP大鼠进行造模检测，造模大鼠随机被分为模型对照组（MC组）、长时间中强度跑步组（LM组）、分段低强度跑步组（SL组），未进行建模的大鼠为正常对照组（NC组）。第12周开始对各组大鼠进行为期12周的运动干预。第25周时进行大鼠各类样本采集和骨密度（bone mineral density, BMD）检测、生物力学性能测量、胰岛素抵抗检测、糖脂代谢检测。结果 ①LM、SL组大鼠BMD明显高于MC组（P＜0.05）；②LM、SL组大鼠股骨最大应力、最大载荷、断裂载荷、弹性模量明显高于MC组（P＜0.05）；③LM、SL组大鼠的OC、ALP、DPD、Ca /Cre、P/Cre指标明显低于MC组（P<0.05）；④LM、SL组大鼠的TG、TC、LDL指标明显低于MC组（P＜0.05）；SL组大鼠的TG、TC、LDL指标明显低于LM组（P＜0.05）；⑤LM、SL组大鼠的FINS、FPG、HOMA-IR、ISI指标明显低于MC组（P＜0.05）；SL组大鼠的FINS、FPG、HOMA-IR、ISI指标明显低于LM组（P＜0.05）。结论分段低强度跑和持续中强度跑均有助于糖尿病性骨质疏松大鼠控制血糖、缓解胰岛素抵抗、改善胰岛素敏感性、降低血脂，同时还增加了骨密度、降低了骨吸收并改善了其股骨骨生物力学性能。

英文摘要:

Objective To demonstrate the feasibility of a segmented multiple low-intensity aerobic exercise approaching as the general lifestyle mode of exercise prescription for patients with diabetic osteoporosis (DOP). Methods A randomized controlled animal experiment was conducted in this study. Diet control was conducted in 100 rats. The feed was fed 5 times a day. On 4-10 weeks, 75 rats were subjected to DOP modeling. On the 11th week, modeling tests were conducted on DOP rats. The modeled rats were randomly divided into model control group (MC group), long-term medium-strength running group (LM group), and segmented low-intensity running group (SL group). The non-modeled rats were as normal controls (NC group). On the 12th week, rats in each group received a 12-week exercise intervention. On the 25th week, various samples were collected and bone mineral density (BMD), biomechanical properties, insulin resistance, and glucose and lipid metabolism were detected. Results ①BMD in LM and SL groups was significantly higher than that in MC group (P<0.05); ②The maximal stress, maximum load, fracture load, and elastic modulus of the femur in the LM and SL groups were significantly higher than those in the MC group (P<0.05); ③ OC, ALP, DPD, Ca/Cre, and P/Cre index in the LM and SL groups were significantly lower than those in MC group (P<0.05); ④TG, TC, and LDL indexes in LM and SL rats were significantly lower than those in MC group (P<0.05). TG, TC, and LDL indexes in SL group were significantly lower than those in LM group (P<0.05);⑤FINS, FPG, HOMA-IR, and ISI indexes in LM and SL rats were significantly lower than those in MC group (P<0.05). FINS, FPG, HOMA-IR, and ISI indexes in SL group were significantly lower than those in LM group (P<0.05). Conclusion Both segmented low-intensity running and continuous medium-intensity running could help to control blood sugar, to alleviate insulin resistance, to improve insulin sensitivity, to reduce blood lipids, to increase BMD, to reduce bone resorption, and to improve the bone biomechanical properties of the femurs in DOP patients.

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