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| 血清戊糖素水平与骨质疏松性椎体压缩性骨折相关性研究 |
| Correlation between serum pentosidine level and osteoporotic vertebral compression fracture |
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| DOI：10.3969/j.issn.1006-7108.2020.06.015 |
| 中文关键词: 椎体压缩性骨折 骨质疏松 戊糖素 |
| 英文关键词:vertebral compression fracture osteoporosis pentosidine |
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| 中文摘要: |
| 目的 探讨血清戊糖素水平与骨质疏松性椎体压缩性骨折(osteoporosis vertebral compression fracture,OVCF)的相关性。方法 对120例接受骨密度检查患者的血清戊糖素水平进行前瞻性分析；采用酶联免疫吸附试验(ELISA)测定受试者血清戊糖素水平；将受试者分为椎体骨折组（33例）及非骨折组（87例）；使用亚洲版骨折风险评估(FRAX)工具评估受试者10年内骨折的概率。结果 椎体骨折组(110.8 ng/mL)和非骨折组(64.3 ng/mL)血清戊糖素水平比较差异有统计学意义(P=0.04)；Logistic回归分析显示血清戊糖素与OVCF显著相关。椎体骨折组的严重骨质疏松性骨折的10年概率明显高于非骨折组(P<0.05)，椎体骨折组的骨质疏松性骨折发生率高于非骨折组(P<0.0 5)。戊糖素水平与FRAX结果呈正相关(r=0.35，P=0.02)。结论 血清戊糖素水平升高和OVCF的发生密切相关。 |
| 英文摘要: |
| Objective To explore the correlation between serum pentosidine levels and osteoporotic vertebral compression fractures (OVCF).Methods Prospectively analyzed the serum pentose levels of 120 patients who underwent bone mineral density examination;Serum pentosidine level was evaluated using enzyme-linked immunosorbent assay. Among all the patients, 33 with OVCF were assigned to the vertebral fracture group and 87 who did not have vertebral fracture were included in the non-fracture group. In addition, we used the Fracture Risk Assessment (FRAX) tool Korean version to assess the 10-year probability of fracture. Results There was a statistically significant difference in the mean serum pentosidine level ( P =0.04) of the vertebral fracture group (110.8 ng/mL) and the non-fracture group (64.3 ng/mL). Logistic regression analyses showed that serum pentosidine was significantly associated with OVCF. The 10-year probability of severe osteoporotic fractures in the vertebral fracture group was significantly higher than that in the non-fracture group (P <0.05), and the incidence of osteoporotic fractures in the vertebral fracture group was higher than that in the non-fracture group (P <0.05).There was a positive correlation between pentosidine level and FRAX results ( r =0.35, P=0.02).Conclusions The elevated serum pentose levels were closely related to the occurrence of OVCF. |
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