| Objective To explore and to analyze the correlation between glucose metabolism and bone metabolism in perimenopausal osteoporosis (OP) patients with type 2 diabetes mellitus (T2DM). Methods Seventy perimenopausal OP patients with T2DM, 70 perimenopausal patients with OP only, and 70 perimenopausal patients with T2DM only were divided into study group, OP group, and T2DM group, respectively. Glucose metabolic indexes and bone metabolic indexes were detected. Results There was no significant difference in the general data among the three groups (P>0.05). The levels of FPG, FINS, HbA1c, HOMA-IS, BGP, ALP, PTH, and the ratio of abnormality among the three groups were statistically significant (P<0.05). The levels of FPG, FINS, HbA1c, and PTH in the study group were significantly higher than those in OP group and T2DM group (P<0.05). The levels of FPG, FINS, and HbA1c in T2DM group were significantly higher than those in OP group (P<0.05). The level of PTH in OP group was significantly higher than that in T2DM group (P<0.05). HOMA-IS, BGP, and ALP in study group were significantly lower than those in OP group and T2DM group (P<0.05). HOMA-IS in T2DM group was significantly lower than that in OP group (P<0.05). BGP and ALP in OP group were significantly lower than those in T2DM group (P<0.05). Comparing the proportions of abnormal glycol-metabolic indexes, study group>T2DM group>OP group. Comparing the proportions of abnormal BGP, ALP and PTH, the study group> OP group>T2DM group. In the study group, FPG, FINS, and HbA1c were negatively correlated with BGP and ALP (r<0, P<0.05), but were positively correlated with PTH (r>0, P<0.05). HOMA-IS was positively correlated with BGP and ALP (r>0, P<0.05), but was negatively correlated with PTH (r<0, P<0.05). Conclusion Most of the perimenopausal OP patients with T2DM may have abnormal glucose metabolism and bone metabolism of BGP, ALP and PTH, and the above-mentioned glucose metabolism and bone metabolism indicators are correlated. |