|
| PCBs对骨代谢影响的相关机制研究进展 |
| Progress of the mechanism of effect of PCBs on bone metabolism |
| |
| DOI：10.3969/j.issn.1006-7108.2020.06.028 |
| 中文关键词: 多氯联苯 骨密度 骨质疏松 骨代谢 |
| 英文关键词:polychlorinated biphenyls bone mineral density osteoporosis bone metabolism |
| 基金项目:中国医科大学大学生创新创业训练计划资助项目（201810159113） |
|
| 摘要点击次数: 692 |
| 全文下载次数: 515 |
| 中文摘要: |
| 多氯联苯（polychlorinated biphenyls，PCBs）是一种已知的持久性有机污染物，具有亲脂性、迁移性和高毒性的特性，可在机体的脂肪组织中蓄积。PCBs因其对人体健康的危害备受关注，研究发现PCBs可引起内分泌紊乱，具有致癌性、发育毒性和骨骼毒性等。PCBs的暴露增加了骨骼疾病的发生率和严重程度，可以增加骨质疏松的风险。PCBs可通过ER依赖的信号通路和RANK-RANKL通路发挥模拟雌激素效应、抗雌激素效应和抗雄激素效应，也能通过调节相关标记基因的表达和细胞凋亡抑制成骨细胞分化和干扰破骨细胞活化等干扰骨代谢，还可通过影响microRNAs的表达调控骨吸收造成骨内稳态失衡，从而引起骨密度等性质的改变。国内外关于PCBs造成骨组织性质改变的内在机制尚未彻底阐明，笔者就PCBs暴露对骨代谢的影响以及相关作用机制进行综述。 |
| 英文摘要: |
| Polychlorinated biphenyls (PCBs) are known as persistent organic pollutants (POPs) with lipophilic, migratory, and highly toxic properties. PCBs has attracted much attention because of its harm to human health. Studies have found that PCBs can cause endocrine disorders and have carcinogenicity, developmental toxicity, and skeletal toxicity. Exposure to PCBs increases the incidence and severity of bone disease and increases the risk of osteoporosis. PCBs play a to estrogen-like effect, anti-estrogen effect, or anti-androgen effect via ER dependent signaling pathway and the RANK-RANKL pathway. They also inhibit osteoblast differentiation and interfere osteoclast activation through regulation of related marker gene expression and cell apoptosis. In addition, PCBs cause bone homeostasis unbalance by interfering the expression of microRNAs to regulate bone resorption, resulting in the change in bone mineral density. The internal mechanism of bone tissue property changes induced by PCBs has not been fully elucidated. This article reviews the effect of PCBs exposure on bone metabolism and its mechanism. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |