中药治疗肾虚血瘀证2型糖尿病合并骨质疏松症患者用药规律研究
Study on the regularity of traditional Chinese medicine for the treatment of type 2 diabetes mellitus complicated with osteoporosis in patients with kidney deficiency and blood stasis syndrome
  
DOI:10.3969/j.issn.1006-7108.2020.07.002
中文关键词:  2型糖尿病  骨质疏松  肾虚血瘀证  数据挖掘  茯苓  中医中药
英文关键词:type 2 diabetes mellitus  osteoporosis  kidney deficiency and blood stasis syndrome  data mining  poria cocos  traditional Chinese medicine
基金项目:国家自然科学基金(81603574,81774286);国家重点研发计划“中医药现代化研究”重点专项(2018YFC1704202);国家中医临床研究基地业务建设第二批科研专项(JDZX2015123);安徽省自然科学基金(1708085QH213)
作者单位
赵进东1,2 忻凌1 余婵娟1 舒仪琼1 吴吉萍1 鲍陶陶1 石国斌1 刘剑1 郭呈林1 方朝晖1,3* 1.安徽中医药大学第一附属医院安徽 合肥 230031 2.安徽中医药大学第一临床医学院安徽 合肥 230031 3.安徽省中医药科学院糖尿病研究所安徽 合肥 230038 
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中文摘要:
      目的 探讨中药治疗肾虚血瘀证2型糖尿病合并骨质疏松症患者用药规律。方法 收集中药治疗193例肾虚血瘀证2型糖尿病合并骨质疏松症患者病案资料,通过数据挖掘技术和关联规则分析中药治疗的频次、四气五味归经、核心药物、药对等。结果 共搜集处方582首,含药255味。有茯苓、白术、黄芪、泽泻、生地、桂枝应用频次超过40%;温性药92味,甘味药156味,入肝经药123味。复杂网络图显示茯苓、红花、黄芪、泽泻、白术、桂枝、陈皮、柴胡为核心药物。中药药对关联规则显示白术-茯苓、茯苓-山药、白术-陈皮、山药等为常用药对。结论 初步总结通过寒温并用、补泻兼顾、以甘味为主的补肾健脾活血中药治疗肾虚血瘀证2型糖尿病合并骨质疏松症患者的用药规律。
英文摘要:
      Objective To explore the regularity of traditional Chinese medicine for the treatment of type 2 diabetes mellitus complicated with osteoporosis in patients with kidney deficiency and blood stasis syndrome. Methods Medical information of 193 cases with kidney deficiency and blood stasis syndrome and type 2 diabetes mellitus complicated with osteoporosis treated with Chinese medicine was collected. The frequency of traditional Chinese medicine treatment, four gas and five flavors, core herbs, and herb pairs, et al., were analyzed through data mining technology and association regularity. Results A total of 582 prescriptions were collected, containing 255 type of herbs. The application frequency of poria cocos, atractylodes macrocephala koidz, astragalus membranaceus, alisma orientale, rehmannia, and cinnamomum cassia presl were more than 40%. There were 92 warm herbs, 156 sweet herbs, and 123 meridian belonging to the liver herbs. Complex network diagram showed that poria cocos, carthamus tinctorius, astragalus membranaceus, alisma orientale, atractylodes macrocephala koidz, cinnamomum cassia presl, citrus reticulata blanco, and bupleurum chinense were the core herbs. The association regularity of traditional Chinese medicines showed that atractylodes macrocephala koidz - poria cocos, poria cocos - dioscotea opposita thunb, atractylodes macrocephala koidz - citrus reticulata blanco and dioscotea opposita thunb, et al., were commonly used herb pairs. Conclusion It is preliminarily summarized that the herb medication regularity is characterized by cold together with warm, complementary together with diarrhea, and mainly sweet for kidney deficiency and blood stasis patients with type 2 diabetes mellitus complicated with osteoporosis.
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