| Objective To investigate the effect of strengthening tendon and bone prescription on bone mineral density, biomechanical properties, and bone histomorphology in ovariectomy-induced osteoporosis rats. Methods The model of postmenopausal osteoporosis was established with classical ovariectomy in female rats. The rats were randomly divided into 6 groups: Sham group, model group (OVX), control group (E2, 12 μg/ kg?d), and low, middle, and high dose strengthening tendon and bone prescription group (JGG 5.56 g/kg?d, JGZ 11 g/kg?d, and JGD 22 g/kg?d, respectively). After feeding for 12 weeks, bone mineral density, biomechanical properties, and bone histomorphology were observed. Results Compared with those in Sham group, the bone mineral density, bone mineral content, and biomechanical properties of the femur in OVX group decreased, and the bone tissue morphology were destroyed. Compared with those in OVX group, the biomechanical properties, bone mineral density, bone mineral content, and bone microstructure in E2 group and three strengthening tendon and bone prescription dose groups improved in varying degrees. Conclusion Strengthening tendon and bone prescription improves bone mineral density and biomechanical properties in postmenopausal osteoporosis rats to some extent, and it is dose-dependent within this dose range. |