|
| 维生素B12和叶酸干预对绝经后骨质疏松症妇女的骨代谢及同型半胱氨酸水平的影响 |
| Effects of vitamin B12 and folic acid intervention on bone metabolism and homocysteine levels in postmenopausal women with osteoporosis |
| |
| DOI：10.3969/j.issn.1006-7108.2020.07.012 |
| 中文关键词: 同型半胱氨酸 叶酸 维生素B12 骨密度 骨生物标志物 骨质疏松 |
| 英文关键词:homocysteine folic acid vitamin B12 bone mineral density bone biomarkers osteoporosis |
| 基金项目: |
|
| 摘要点击次数: 751 |
| 全文下载次数: 427 |
| 中文摘要: |
| 目的 观察叶酸和维生素B12对绝经后骨质疏松症妇女的骨代谢及同型半胱氨酸水平的影响。方法 80例绝经后骨质疏松症妇女参加研究。所有参与者随机接受叶酸和维生素B12(n=40)或安慰剂(n=40)治疗。在干预前的基线及干预后3个月和6个月，测量两组患者血清同型半胱氨酸、维生素B12和骨代谢标志物的水平。结果 治疗前，两组患者血清同型半胱氨酸、维生素B12和骨代谢标志物水平比较差异无统计学意义(P＞0.05)。治疗后，两组患者同型半胱氨酸均下降，但比较差异无统计学意义(P＞0.05)。 6个月后各组间血清维生素B12、骨钙素、CTX的变化均有显著改变且差异有统计学意义(P＜0.05)。结论 绝经后骨质疏松症妇女补充叶酸和维生素B12可以一定程度改善同型半胱氨酸及骨代谢指标水平。 |
| 英文摘要: |
| Objective To observe the effects of folic acid and vitamin B12 on bone metabolism and homocysteine levels in postmenopausal women with osteoporosis. Methods Eighty postmenopausal osteoporotic women were enrolled in the study. All the participants were randomized to receive folic acid and vitamin B12 (n=40) or placebo (n=40). Levels of homocysteine, vitamin B12, and bone biomarkers were measured at baseline, 3 months, and finally 6 months post intervention, respectively. Results Before the treatment, the levels of homocysteine, vitamin B12, and bone biomarkers were similar in both groups at baseline. After the treatment, homocysteine decreased in both groups with no statistical significance (P>0.05). The changes of the serum levels of vitamin B12, osteocalcin, and CTX were significant between the two groups after 6 months (P<0.05). Conclusion Supplementation of folic acid and vitamin B12 may improve the levels of homocysteine and the rate of bone metabolism in postmenopausal women with osteoporosis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |