Objective To investigate the secondary osteoporosis and related influencing factors in patients with rheumatoid arthritis (RA). Methods Eighty RA patients were enrolled. Bone mineral density (BMD) of the total hip, lumbar vertebrae L1-4, femoral neck, and Ward's area was measured using dual-energy X-ray absorptiometry. Patients were divided into groups according to BMD. There were 35 patients in the normal group, 26 patients in the bone mass reduction group, and 19 patients in the osteoporosis group. Radioimmunoassay was used to measure bone metabolism markers, including osteocalcin (OC), sputum collagen cross-linking protein carboxy terminal peptide (SCTX), bone-specific alkaline phosphatase (BAP). Meanwhile, the disease activity indicators in RA patients, including C-reactive protein (CRP), rheumatoid factor (RF), and erythrocyte sedimentation rate (ESR) were measured. Logistic regression was used to analyze the influencing factors of osteoporosis (OP) in patients with RA. Results Female gender, fracture history, aging, history of taking glucocorticoids, duration of disease, and RF were risk factors for secondary OP in RA, and BMI was a protective factor for secondary OP in RA. Conclusion Gender, age, and previous fracture history are significant factors in the development of osteoporosis in patients with RA. The severity of osteoporosis is related to the length of the disease and the degree of disease activity. |