| Objective To observe the effect of quercetin on bone metabolism in osteoporotic elderly patients treated with bisphosphonates. Methods Two hundred and sixteen senile patients with osteoporosis (admission time: 2017.1-2018.1) were divided into routine control group (108 cases, treated with bisphosphonates + bone health supplement for 6 months) and quercetin supplement group (108 cases, treated with bisphosphonates + bone health supplement + quercetin for 6 months). The differences of subjective and objective efficacy (total effective rate, ODI score, SF-36 score, and VAS visual score), bone mineral density, and bone metabolic index (CTX-1, BALP, BGP, t PINP, PTH) between the conventional control group and quercetin supplement group were analyzed. Results Compared with those before the treatment, BMD, BALP, and SF-36 scores of the distal forearm in both quercetin supplementation group and conventional control group increased, while VAS, ODI score, and bone metabolic index (PTH, BGP, CTX-1, t PINP) decreased (all P < 0.05). BMD, BALP, and SF-36 of the distal forearm in quercetin supplementation group increased more (all P<0.05), and VAS, ODI, and bone metabolism index (PTH, BGP, CTX-1, t PINP) decreased more. The total clinical effective rate of quercetin supplementation group (87.04%) was significantly better than that of routine control group (68.52%, P<0.05). Conclusion Quercetin supplementation can significantly relieve the abnormal level of bone mineral density, pain symptom, dysfunction, and bone metabolism in elderly patients with osteoporosis, and improve the quality of life of the patients. |