| Objective To investigate the effect of simvastatin combined with alendronate on bone metabolism in ovariectomized osteoporosis rats. Methods Sixty female SD rats were randomly divided into 5 groups: sham operation group, castration group, simvastatin group, alendronate group, and combination group. The osteoporosis model was established in ovariectomized rats. Biochemical markers related to bone metabolism, biochemical indicators of oxidative stress, and BMD of bone tissue were examined. Bone histomorphology was observed with HE staining. Results The serum levels of Ca, P, SOD, CAT, and BMD in the ovariectomized group were significantly lower than those in the sham operation group (P<0.05). The above indexes in simvastatin group, alendronate group, and combination group were higher than those in the ovariectomized group. The most significant increase was in the combination group (P<0.05). The serum levels of ALP, BGP, PICP, TRAP, GLA, ICIP, and MDA in the ovariectomized group were significantly higher than those in the sham operation group (P<0.05). The above indicators in the simvastatin group, the alendronate group, and the combination group were lower than those in the ovariectomized group. The most significant reduction was in the combination group (P<0.05). The castrated trabecular bone in the ovariectomized group was obviously sparse, the connection was incomplete, and a large amount of fibrous tissue and more vacuolar fat cells were found in the medullary cavity. The number of trabecular bone in the combined drug group increased significantly. The structure was relatively completed, the thickness was uniform and dense, and the mesh was connected. Conclusion Simvastatin combined with alendronate inhibits bone metabolism, anti-oxidative stress, increases bone mineral density, improves bone structure, and exerts anti-osteoporosis effects. |