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| 绝经后2型糖尿病患者Irisin水平分析 |
| An irisin level analysis of postmenopausal patients with type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1006-7108.2020.08.002 |
| 中文关键词: 绝经后 2型糖尿病 骨量 鸢尾素 |
| 英文关键词:postmenopausal women type 2 diabetes mellitus bone mass irisin |
| 基金项目:国家自然科学基金（81460168）；贵州省自然科学基金资助项目[黔科合基础（2020）1Y314]；遵义医科大学新苗培养及创新探索专项后补助课题[黔科合平台人才(2017)5733-043]；遵义市联合基金[遵市科合社字(2018)63] |
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| 中文摘要: |
| 目的 通过检测绝经后初诊2型糖尿病（type 2 diabetes mellitus，T2DM）不同骨量人群血清中鸢尾素(Irisin)、25羟维生素D[25-hydroxyvitamin D，25(OH)D]水平，初步探讨其在绝经后初诊糖尿病患者骨量流失过程中的作用及意义。方法 选取在遵义医科大学院附属医院内分泌科住院的绝经T2DM女性病人150例，根据骨密度(bone mineral density, BMD)分为T2DM骨量正常组（A组，50例）、T2DM骨量减少组（B组，50例）、T2DM骨质疏松组（C组，50例），收集同期医院体检中心相匹配的绝经后健康女性体检者为正常对照组（NC组，50例）。采用酶联免疫吸附法（enzyme linked immunosorbent assay，Elisa）测定所有受试者血清Irisin水平。运用Pearson相关分析绝经后T2DM合并骨质疏松（osteoporosis,OP）患者血清Irisin与25(OH)D的相关性；通过Logistic回归分析绝经后T2DM病人骨密度的影响因素。结果 A组与B组相比，BMD（Neck,L1~4)、Irisin升高，LDL-C、FINS、HbA1c、FPG、HOMA-IR明显降低，差异均具有统计学意义(P＜0.05)；Pearson相关分析显示,Irisin与HbA1c、FPG、FINS、HOMA-IR、LDL-C均呈负相关，与BMD（Neck、L1~4）、25(OH)D呈正相关。结论 血清中Irisin、25(OH)D水平随着骨量流失而逐渐减低，推测其可能共同参与了绝经后女性发生糖代谢紊乱及骨量流失的过程。 |
| 英文摘要: |
| Objective To preliminarily explore the potential roles and significance of serum irisin and 25-hydroxyvitamin D [25(OH)D] in the process of bone mass loss in postmenopausal initially diagnosed diabetic patients by detecting their levels in postmenopausal patients initially diagnosed with type 2 diabetes mellitus (T2DM) with different bone masses. Methods A total of 150 postmenopausal patients with T2DM admitted to our department of endocrinology were randomly assigned, depending on the bone mineral density (BMD), to the T2DM+normal bone mass group (Group A), T2DM+osteopenia group (Group B), or the T2DM+osteoporosis group (Group C), each including 50 patients; 50 matching postmenopausal healthy women receiving physical examination at our hospital over the same period were assigned to the normal control group (NC group). Serum irisin was determined using enzyme linked immunosorbent assay (ELISA) for all the subjects. Pearson correlation analysis was performed to analyze the correlation between serum irisin and 25(OH)D in postmenopausal T2DM patients with osteoporosis (OP); Logistic regression analysis was performed to analyze the influencing factors for bone mineral density in postmenopausal T2DM patients. Results Compared with Group B, BMD (L1-4), BMD (Neck) and irisin were increased, and LDL-C, FINS, HbA1c, FPG and HOMA-IR were significantly decreased in Group A, with statistically significant differences (P<0.05); there were no significant differences between Group A and Group B in TC, TG or 25(OH)D (P>0.05). Pearson correlation analysis showed that irisin was negatively correlated with HbA1c, FPG, FINS, HOMA-IR and LDL-C, and positively correlated with BMD (Neck, L1-4) and 25(OH)D. Conclusion Serum levels of Irisin and 25(OH)D decreased gradually with bone loss, suggesting that they may be jointly involved in the process of glucose metabolism disorder and bone loss in postmenopausal women. |
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