| Objective To investigate the osteopenia or osteoporosis in rheumatoid arthritis focused on male patients and the risk factors. Methods Seventy-eight cases who attended in our hospital from August 2013 to May 2019 were selected, including 38 patient (64.39±9.44 years old) with rheumatoid arthritis and 40 healthy normal people (63.53±8.14 years old). The lumbar spine (L1-4) and left femoral neck (FN), femoral trochanter (Troch), the Ward's triangle (Ward's) and total hip (Total) BMD were detected by DXA; the levels of BAP, BGP and CTX were determined by electrochemiluminescence immunoassay. The ESR,CRP, number of swollen joints and tender joint count, RF and CCP of patients with rheumatoid arthritis were examined. The differences in bone mineral density and bone biochemical indexes between the two groups were analyzed and compared., Single factor and multivariate Logistic regression analysis were used to indentify risk factors for osteoporosis in patients with RA. Results There was no significant difference in age and body mass index (BMI) between the two groups(P>0.05). The frequency of osteopenia or osteoporosis among male patients with RA was significantly higher than that among controls (P<0.05) and RA patients had a significantly lower femoral neck and total hip BMD than health individuals (P<0.05). The CTX levels in RA group was higher than control group (P<0.05).Single analysis indicated 4 factors associated with osteoporosis in male patients with RA, including BMI,CRP,DAS28-ESR and CTX. In multivariable logistic regression models, BMI<18.5 kg/m2（OR=0.014）, DAS28-ESR>5.1（OR=21.433）and CTX>0.7 ng/mL（OR=25.875）were the independent risk factors for osteoporosis at either site in male patients with RA. Conclusion Male patients with RA are prone to osteoporosis, and the risk factors such as BMI, DAS28 and CTX should be highly valued. |