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| 经线粒体途径相关信号通路对成骨细胞的影响 |
| Effects of mitochondrial pathway and related signaling pathways on osteoblasts |
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| DOI：10.3969/j.issn.1006-7108.2020.08.028 |
| 中文关键词: 成骨细胞 骨质疏松 线粒体途径 信号通路 |
| 英文关键词:osteoblasts osteoporosis mitochondrial pathway signaling pathway |
| 基金项目:兰州市科技发展计划（2016-3-121）；兰州大学学生创新创业行动计划（20190050003）；兰州大学第二医院“萃英学子科研培育”计划（CYXZ2019-03） |
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| 中文摘要: |
| 骨质疏松是骨科的常见病症，是以骨微观结构改变、骨脆性增加、骨量减少为特征的全身代谢性骨质病变。成骨细胞与破骨细胞对骨组织形成、破坏作用的失衡是骨量丢失的主要成因。因此，抑制成骨细胞的凋亡是治疗骨质疏松的关键。现已知，成骨细胞的凋亡主要是由线粒体凋亡途径有关的多种信号通路和多种细胞因子作用导致。本文主要对线粒体凋亡途径及相关信号通路PI3K-Akt、MAPK、Wnt/β-catenin、NF-κB通路和其中的关键靶点作一综述，并阐述部分信号通路之间的作用及其对成骨细胞凋亡的影响，对深入研究骨质疏松的发病机制及研发有关治疗新药有重大意义。 |
| 英文摘要: |
| Osteoporosis (OP) is a common condition in orthopedics. It is a systemic metabolic bone lesion which characterized by bone microstructural changes, increased bone fragility, and reduced bone mass. The imbalance between osteoblast formation and destruction by osteoblasts (OB) and Osteoclis (OC) is the main cause of bone loss. Therefore, inhibiting apoptosis of osteoblasts is the key to treat osteoporosis. It is known that apoptosis of osteoblasts is mainly caused by multiple signaling pathways involved in the mitochondrial apoptotic pathway and various cytokines. This review focuses on the mitochondrial apoptotic pathway, PI3K-Akt, MAPK, Wnt/β-catenin, NF-κB pathways and their key targets, and describes the role of some signaling pathways and their effects on osteoblast apoptosis. It has great significance for the in-depth study of the pathogenesis of osteoporosis and the development of new drugs for treatment. |
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