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| 绝经后骨质疏松症发病机制的表观遗传学研究进展 |
| Advances in the pathogenesis and epigenetics of postmenopausal osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2020.08.030 |
| 中文关键词: 表观遗传学 绝经后骨质疏松症 DNA甲基化 组蛋白修饰 非编码RNAs |
| 英文关键词:epigenetics postmenopausal osteoporosis DNA methylation histone modification noncoding RNAs |
| 基金项目:国家自然科学基金项目（81503601）；中华中医药学会青年人才托举工程（NQRC2-C08）；北京中医学大学东直门医院青苗人才培养计划（DZMYS-201802) |
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| 中文摘要: |
| 表观遗传学修饰是指在DNA序列未变化情况下发生可遗传的基因表达的变化，主要机制包括DNA甲基化、组蛋白修饰、非编码RNAs、染色质修饰等。绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)属于原发性骨质疏松症的一种，主要是由于绝经后女性激素水平改变等原因致使骨代谢失衡，骨微结构破坏，骨量减少。近年来，大量研究证实了表观遗传学参与绝经后骨质疏松症的发生发展，本文将从DNA甲基化、组蛋白修饰和非编码RNAs这三个方面综述绝经后骨质疏松症在表观遗传学方面的发病机制。 |
| 英文摘要: |
| Epigenetic modification refers to the changes in the expression of heritable genes without changes in the DNA sequences. The main mechanisms include DNA methylation, histone modification, non-coding RNAs, chromatin modification, etc. Postmenopausal osteoporosis (PMOP) is a type of primary osteoporosis, mainly due to changes in hormone levels and other causes in postmenopausal women lead to imbalance of bone metabolism, bone microstructural destruction and bone mass loss.In recent years, a large number of studies have confirmed that epigenetics is involved in the occurrence and development of postmenopausal osteoporosis. In this paper, the pathogenesis of postmenopausal osteoporosis in epigenetics will be reviewed from three aspects: DNA methylation, histone modification and non-coding RNAs. |
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