| Objective To investigate the association between serum ferritin (SF), cystatin C (Cys-C) and bone mineral density (BMD) in postmenopausal women. Methods Four hundred and Ninety-two postmenopausal women aged from 55 to 80 with complete clinical data were collected from the physical examination center of Nantong first people's Hospital from October 2015 to April 2019. Serum samples were collected to detect SF, Cys-C, Scr, PTH, 25OHD, OC, PⅠNP, and β-CTX. BMD of the femoral neck, total femur, and 1-4 lumber vertebrae were measured with dual energy X-ray absorptiometry. Results The incidence of osteoporosis was 46.5% in our study. There were significant differences in age, weight, BMI, SF, Cys-C, 25OHD, PⅠNP, and β-CTX among different BMD groups. In the quartile groups of SF and Cys-C, there were statistically significant differences in age, weight, BMI, Scr, and T value of BMD. Higher SF and Cys-C levels were associated with a higher prevalence of osteoporosis in postmenopausal women (OR=2.272, 95% CI, 1.090-4.727 and OR=2.224, 95% CI, 1.047-4.723, respectively) after adjusted for age, weight, BMI, Scr, 25OHD, and PⅠNP. Conclusion The increase of SF and Cys-C are independent risk factors for postmenopausal osteoporosis. It is necessary to pay attention to the changes of SF and Cys-C in postmenopausal women. |