| Objective To analyze the effect of liraglutide on miRNA-19a, miRNA-144, and bone density in rats with type 2 diabetes and osteoporosis (DOP). Methods Random number table method was used to randomly divide 50 rats into normal group, castration control group, model group, and drug administration group. DOP rat model was constructed in model group and drug administration group. Rats were removed bilateral ovaries in castration control group. Rats in the normal group, castration control group, and model group were treated with normal saline. Rats in the drug group received liraglutide. After the treatment, blood samples of rats were collected to detect levels of blood glucose, insulin, Cad-11, IRS1, miRNA-19a, and miRNA-144. Bone mineral density of the lumbar spine, whole body, pelvis, and femur was detected using dual-energy X-ray absorptiometry. Results The levels of blood glucose, miRNA-19a, miRNA-144, Cad-11, and IRS1 in the drug administration group were significantly better than those in the model group and castration control group. Bone mineral density of the rats in the drug administration group was significantly higher than that in the castration control group and model group. Conclusion Liraglutide inhibits the decrease of bone mineral density in diabetic rats, and its effect may be related to the reduction of miRNA-19a and miRNA-144 levels in type 2 DOP rats. |