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| 血清维生素D和K水平和慢性胰腺炎患者骨质疏松症相关性研究 |
| Correlation between serum vitamin D and K levels and osteoporosis in patients with chronic pancreatitis |
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| DOI：10.3969/j.issn.1006-7108.2020.09.014 |
| 中文关键词: 维生素D 维生素K 慢性胰腺炎 骨密度 骨质疏松症 |
| 英文关键词:vitamin D vitamin K chronic pancreatitis bone mineral density osteoporosis |
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| 中文摘要: |
| 目的 探索血清维生素D和K水平和慢性胰腺炎患者骨质疏松症相关性。方法 通过双能X射线吸收测定法检测骨密度和粪弹性蛋白酶检测评估胰腺功能；检测患者血清维生素D和维生素K的水平；通过逻辑回归分析研究变量与骨密度之间的关联。结果 共有211名CP患者，其中男性142例。有18 %的患者有晚期CP，患有胰腺外分泌功能不全为43 %。维生素D和K缺乏分别为56 %和32 %。骨量减少的诊断率为42 %，骨质疏松症的诊断率为22％。在多变量分析中，女性、年龄和较高BMI与骨质疏松症存在相关性。在男性患者中，与骨质疏松症相关的唯一因素是维生素K缺乏症。结论 CP患者的骨病发生率很高，且维生素K缺乏作为男性骨质疏松症患者唯一的危险因素。 |
| 英文摘要: |
| Objective To explore the correlation between vitamin D and K levels and osteoporosis in patients with chronic pancreatitis (CP). Methods Bone mineral density was determined using dual-energy X-ray absorptiometry. Faecal elastase was detected to evaluate pancreatic function. Nutritional evaluation included vitamin D and vitamin K. The association between investigated variables and bone mineral density were analyzed with logistic regression analysis. Results A total of 211 CP patients were enrolled (67% men; mean age 60 years old). In total, 18% of the patients had advanced CP, 56% suffered from pancreatic exocrine insufficiency, and 43% had alcoholic etiology. Vitamin D and K were deficient in 56% and 32%, respectively. Osteopenia was diagnosed in 42% and osteoporosis in 22%. In the multivariate analysis, female sex (OR=2.78), age (OR=1.07 per year), and higher BMI (OR=0.84) were associated with the presence of osteoporosis. In male patients, the only factor associated with osteoporosis was vitamin K deficiency (OR=4.23). Conclusion The present data confirm a high rate of osteopathy in CP patients and highlight the relevance of vitamin K deficiency as the only factor associated with osteoporosis in male patients. |
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