| Objective To observe the clinical characteristics of bone mineral density and bone metabolic markers in premenopausal women over 40 years old in Guangzhou. Methods Among the 1170 females who were included in the epidemiological survey of osteoporosis in Guangzhou from March 2017 to April 2017, 131 premenopausal women (43-59 years old) with complete data and meeting inclusion criteria were selected as the study subjects. General data such as height, weight, body mass index, and waist and hip circumference, etc. were recorded and analyzed. Serum levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone, osteocalcin, type I procollagen N-terminal propeptide, type I collagen carboxy terminal peptide, and 25-hydroxyvitamin D were detected. Bone mineral density of the lumbar vertebrae 1-4 and left proximal femur was measured using dual energy X-ray absorptiometry, and T and Z values were used for diagnosis. Results (1) According to T values for the diagnosis: 55 cases (42.0%) were in the normal bone mass group, 67 cases (51.1%) were in the osteopenia group, and 9 cases (6.9%) were in the osteoporosis group. According to Z values for diagnosis: 128 cases (97.7%) were in the normal bone mass group and 3 cases (2.3%) were in the osteopenia group. The general data and bone metabolic markers of the patients were compared using T value grouping. Compared with those in the normal bone mass group, the height, weight, body mass index, and waist and hip circumference in the osteoporosis group were not statistically significant. There were no significant differences in the levels of Ca, P, 25(OH)D, and PTH among the three groups. Compared with the normal bone mass or osteopenia group, the bone resorptive marker β-CTX had an increasing trend in the osteoporosis group, and the bone formation marker ALP, OC, and PINP levels increased significantly. Conclusion The sensitivity of the study population to the diagnosis of osteoporosis using T value is higher than using Z value. Osteoporosis occurred in the study population is premenopausal idiopathic osteoporosis. There is no significant association between the onset of pre-menopausal idiopathic osteoporosis and Ca, P, 25(OH)D, and PTH. The high turnover of bone metabolism may be the main mechanism of pathogenesis, and the hereditary factor may be the main cause of the disease. |