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| 阿兹海默症骨骼研究进展 |
| Progress in the research of the bone in Alzheimer’s disease |
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| DOI：10.3969/j.issn.1006-7108.2020.09.032 |
| 中文关键词: 阿兹海默症 骨质疏松症 骨髓间充质干细胞 神经小胶质细胞 micro-RNA |
| 英文关键词:Alzheimer's disease, osteoporosis, bone marrow-derived mesenchymal stem cells, microglia, micro-RNA |
| 基金项目:国家自然科学基金青年项目（2019T120739）；中国博士后科学基金（2019T120739，2019M662962） |
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| 中文摘要: |
| 阿兹海默症和骨质疏松症都是两种常见的多因素的进行性退行性疾病，多发于60岁以上人群，流行病学发现二者具有很高的共病率，但目前对它们之间联系的机制知之甚少。近年来，通过骨源性细胞和其分泌蛋白的作用，证明骨骼与其他几个器官系统相互作用，大脑似乎属于这个相互联系的网络。本文总结国内外大量文献，发现阿兹海默症患者和动物模型的骨表型以骨密度下降、骨质疏松、骨折为主，深入探讨阿兹海默症相关的骨骼信号转导，以及骨骼来源的骨髓间充质干细胞、小胶质细胞、单核细胞、粒细胞集落刺激因子和骨骼相关维生素、micro-RNA对阿兹海默症的影响。试图为阿兹海默症患者骨质疏松的预防和治疗提供新的理论依据，为今后筛选基因辅助治疗阿兹海默症提供关键性靶点，同时也开拓研究阿兹海默症的新思路。 |
| 英文摘要: |
| Alzheimer's disease and osteoporosis are multifactorial progressive degenerative disorders, mostly occurring in people over 60 years old. Epidemiology research shows that they have high comorbidity rate. However, the mechanism of the interaction between them is known little currently. Recently, it has been demonstrated that the bone interacts with several other organ systems through bone derived cells and their secretory protein. The brain seems to belong to this interconnected network. This paper summarizes a large number of national and international literatures, explores that bone phenotypes in patients with Alzheimer’s disease or in animals of Alzheimer’s disease model are bone loss, osteoporosis, and fractures, and explores Alzheimer's disease-related signal transduction in bone, as well as the effects of bone marrow-derived mesenchymal stem cells, microglia, monocyte, granulocyte colony-stimulating factor, bone related vitamins, and micro-RNA on Alzheimer's disease. The paper tries to provide the new theoretical basis for the prevention and treatment of Alzheimer's patients with osteoporosis, to provide the key targets for the treatment of Alzheimer's disease, and to open a new idea of study of Alzheimer's disease. |
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