中国骨质疏松杂志

凝溶胶蛋白与绝经后女性股骨颈及腰椎骨密度的相关性研究

Study on the correlation between gelsolin and bone mineral density of femoral neck and lumbar spine in postmenopausal women

DOI：10.3969/j.issn.1006-7108.2020.10.015

中文关键词: 凝溶胶蛋白绝经股骨颈腰椎骨密度

英文关键词:gelsolin menopause femoral neck lumbar spine bone mineral density

基金项目:江西省卫生计生委中医药科研课题项目（2018A157）

作者	单位
程毅* 江共涛胡和军魏星星徐南云	江西省南昌市洪都中医院，江西南昌 330000

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中文摘要:

目的探讨凝溶胶蛋白（GSN）在绝经后女性血浆中的水平并分析与股骨颈及腰椎骨密度（BMD）的相关性。方法选取我院2015年1月至2019年5月期间在我院正常体检人员。纳入绝经后女性110名。与此同时，在我院体检中心选择非绝经期女性110例。采用Hologic?QDR-4500 DXA骨密度仪测定股骨颈、腰椎（L1-L4）的BMD。BMD数据以g/cm2和T评分表示。T评分＜?2.5定义为骨质疏松症，T评分在?1~?2.5间定义为骨量减少，T评分＞?1定义为骨密度正常（正常BMD组）。骨质疏松症或骨量减少定义为低BMD组，骨密度正常定义为正常BMD组。采用酶联免疫吸附试验（ELISA）测定GSN水平。结果绝经后女性年龄、SBP、DBP、TC、FBS高于绝经前女性（P＜0.05）；而股骨颈-BMD、腰椎(L1-L4)-BMD、GSN低于绝经前女性（P＜0.05）。股骨颈-BMD组中，低BMD组的年龄、吸烟比例、TC、FBS、GSN高于正常BMD组（P＜0.05）；而BMI、HDL低于正常BMD组（P＜0.05）。腰椎(L1-L4)-BMD组中，低BMD组的年龄、TC、FBS、GSN高于正常BMD组（P＜0.05）；而BMI、HDL低于正常BMD组（P＜0.05）。股骨颈-BMD与年龄、吸烟、FBS、pGSN呈负相关（r=?0.435、?0.301、?0.243、?0.609），与HDL、BMI呈正相关（r=0.395、0.365）。腰椎(L1-L4)-BMD与年龄、pGSN呈负相关（r=?0.463、?0.433），与BMI呈正相关（r=0.398）。年龄、BMI、GSN是股骨颈-BMD独立影响因素；年龄、GSN是腰椎(L1-L4)-BMD独立影响因素。结论 GSN是股骨颈-BMD、腰椎(L1-L4)-BMD的独立影响因素。因此，GSN水平升高可能预测绝经后女性骨质疏松症的发生及进展。

英文摘要:

Objective To investigate the content of gelsolin (GSN) in plasma of postmenopausal women and to analyze its correlation with bone mineral density (BMD) of femoral neck and lumbar spine. Methods The normal medical examinees in our hospital from January 2015 to May 2019 were selected. 110 postmenopausal women were included. At the same time, 110 non-menopausal women were selected in the physical examination center of our hospital. BMD of femoral neck and lumbar spine (L1-L4) was measured by Hologic ?QDR-4500 DXA densitometer.BMD data was expressed as g/cm2 and standard deviation score (T score).T score < ?2.5 was defined as osteoporosis, T score between ?1,?2.5 was defined as osteopenia, T score > ?1 was defined as osteopenia (normal BMD group).Osteoporosis or osteopenia was defined as a low BMD group, and normal bone was defined as a normal BMD group. The level of GSN was determined by enzyme-linked immunosorbent assay (ELISA).Results The age, SBP, DBP, TC and FBS of postmenopausal women were higher than those of pre-menopausal women (P< 0.05), while the femoral neck-BMD, lumbar vertebrae (L1-L4) BMD and GSN were lower than those of pre-menopausal women (P< 0.05).In femoral neck-BMD group, age, smoking rate, TC, FBS and GSN in low BMD group were higher than those in normal BMD group (P< 0.05), while BMI and HDL were lower than those in normal BMD group (P< 0.05).In the lumbar spine (L1-L4) BMD group, the age, TC, FBS and GSN of the low BMD group were higher than those of the normal BMD group (P< 0.05), while BMI and HDL were lower than those of the normal BMD group (P< 0.05).Femoral neck-BMD was negatively correlated with age, smoking, FBS and pGSN (r=?0.435, ?0.301, ?0.243, ?0.609), and positively correlated with HDL and BMI (r=0.395, 0.365).Lumbar spine (L1-L4) BMD was negatively correlated with age and pGSN (r=?0.463, ?0.433), and positively correlated with BMI (r=0.398).Age, BMI and GSN were independent influencing factors of femoral neck-BMD, and age and GSN were independent influencing factors of lumbar spine (L1-L4) BMD. Conclusion GSN is an independent influencing factor of femoral neck-BMD and lumbar vertebrae (L1-L4) BMD. Therefore, elevated GSN levels may predict the occurrence and progression of osteoporosis in the postmenopausal women.

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