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| 血清CCL4水平和绝经后骨质疏松症严重程度相关性研究 |
| Correlation between serum CCL4 level and severity of postmenopausal osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2020.10.017 |
| 中文关键词: CCL4 骨密度 绝经后骨质疏松症 疾病严重程度 |
| 英文关键词:CCL4 bone mineral density postmenopausal osteoporosis disease severity |
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| 中文摘要: |
| 目的 探讨血清CCL4水平与绝经后骨质疏松症（PMOP）严重程度的关系。方法 对66名PMOP女性，68名绝经后非骨质疏松女性和67名健康育龄妇女进行研究。用双能X射线吸收测定法扫描评估骨密度。Oswestry残疾指数和视觉模拟量表用于量化症状的活动功能和严重程度。用定量夹心酶联免疫吸附测定血清CCL4水平。结果 发现CCL4血清水平与骨密度呈显著负相关。此外，血清CCL4水平与视觉模拟评分和Oswestry残疾指数评分显著相关。结论 血清CCL4是评估PMOP女性疾病严重程度的潜在生物标志物。 |
| 英文摘要: |
| Objective To explore the relationship between serum CCL4 level and the severity of postmenopausal osteoporosis (PMOP). Methods This research enrolled 66 PMOP females, 68 post- menopausal nonosteoporotic women and 67 healthy women of childbearing age. Bone mineral densities were assessed with dual X-ray absorptiometry scans. The Oswestry disability index and the visual analog scale were employed to quantify functional ability and severity of symptoms. Serum CCL4 levels were examined with a quantitative sandwich enzyme-linked immunosorbent assay. Results We observed a significant negative correlation of CCL4 serum levels with bone mineral density. Furthermore, serum CCL4 concentrations were significantly related to the visual analog scale and Oswestry Disability Index scores. Conclusion Serum CCL4 is a potential biomarker to evaluate disease severity in PMOP females. |
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