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| 基于二仙汤 “仙灵脾-知母” 药对的中医阴阳平衡理论视角探讨中药抗骨质疏松机制研究策略 |
| Mechanism research strategies of anti-osteoporosis of Erxian Decoction based on “Balancing Yin and Yang” in Traditional Chinese Medicine of “Xianlingpi-Zhimu” |
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| DOI：10.3969/j.issn.1006-7108.2020.10.028 |
| 中文关键词: 二仙汤 仙灵脾-知母 阴阳平衡 骨质疏松 研究策略 |
| 英文关键词:erxian decoction Xianlingpi-Zhimu Balancing Yin and Yang osteoporosis research strategies |
| 基金项目:全国第六批国家中医师承项目（KJ180101）；江苏省青年医学人才项目（QNRC2016252）；江苏省苏州市科技发展计划项目（sys2018091） |
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| 中文摘要: |
| 中药验方二仙汤治疗骨质疏松症以其不良反应少、标本兼治等特点，已成为临床常用方药。成骨-破骨细胞耦联的骨稳态与中医“阴阳平衡”理论具有微妙的关联性，骨质疏松发病的根本机制即为骨稳态失衡。既往的研究发现二仙汤之“仙灵脾-知母”药对配伍很可能通过“平衡阴阳”改善骨质疏松，是其抗骨质疏松过程中所隐含的规律性特征与辨证施治内涵体现。依托中医阴阳学说诠释成骨细胞与破骨细胞在骨稳态中的阴阳属性，基于二仙汤“仙灵脾-知母”药对的中医阴阳平衡理论视角探讨抗骨质疏松机制研究的策略，阐明这些方法的基本原理以及应用特点，可为阐释药对配伍规律的科学内涵及优化组方的应用提供重要支撑，也可为其他药对的现代研究提供探索性思路与方法。 |
| 英文摘要: |
| Traditional Chinese medicine such as erxian decoction has become a trend of clinical treatment because it has less side effects and addresses both the symptoms and the root cause. Osteoblasts-osteoclasts coupled bone homeostasis has subtle correlation with the theory of "balancing Yin and Yang" in Traditional Chinese Medicine, and the imbalance of bone homeostasis is the fundamental mechanism of osteoporosis. Previous studies had found that the herb pair “Xianlingpi-Zhimu” for tonifying kidney was likely to improve osteoporosis by "balancing Yin and Yang", which implicated certain regularity and some connotation of erxian decoction for diagnosis and treatment based on an overall analysis of anti-osteoporosis of the illness and the patient's condition. Interpretation basis of Yin-Yang property of osteoblasts and osteoclasts in bone balance, mechanism research strategies of anti-osteoporosis of erxian decoction based on “balancing Yin and Yang” in Traditional Chinese Medicine of “Xianlingpi-Zhimu”, this paper provides important support for elucidating scientific connotation of compatibility regularity of herb pairs and application of formulae optimization, as well as explorative ideas and approaches for modern research on other herb pairs. |
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