| Irisin is a muscle factor that mediates exercise and regulates energy metabolism, it has a good effect in the treatment of obesity, type 2 diabetes, lipid metabolism, cardiovascular disease, bone metabolism disease and so on. Studies have found that exercise can promote the delivering of Irisin, while Irisin can improve bone metabolism through targeting osteoblast directly, improving the regulation of bone genes such as Runx2, Atf4, Spp1 and Sost, having cascade reaction with signaling pathways, including Wnt, BMP (MAPK), OPG/RANKL/RANK, and enhancing aerobic glycolysis as well. As a newly found myokine which works on bone metabolism, Irisin will help us understand that exercise improves bone health better. Besides, it also provides news suggestions of drug treatments for metabolic bone diseases. At present, it has been confirmed that exercise can improve bone metabolism through Irisin mediation, but there is a complex relationship between the secretion of Irisin and exercise type, exercise time, exercise intensity, population, etc. It is known that Irisin can improve bone metabolism, however, relevant studies between them still have a long way to go. The emergence of bone metabolism diseases has forced us to accelerate our understanding of more reasonable ways to improve bone metabolism. This paper summarizes the relations between exercise and Irisin, exercise and bone metabolism and Irisin and bone metabolism to provide references and basis for exercise to improve bone metabolism diseases and treatment of bone metabolism diseases. |