| Objective To explore the correlation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and osteoporosis in elderly patients with type 2 diabetes mellitus. Methods From January 2014 to December 2019, 227 elderly patients with type 2 diabetes mellitus who were admitted to Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University were collected and divided into normal group (40 cases), osteopenia group (56 cases), and osteoporosis group (131 cases) according to the result of bone mineral density (BMD).The general data of the patients were recorded.White blood cell count (WBC), monocyte, lymphocyte, neutrophils, fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and the indexes of thyroid and islet function were examined. MHR level was calculated. BMD of the lumbar spine 1-4 (L1-L4), femoral neck, Wards triangle, and greater trochanter were measured using dual-energy X-ray absorptiometry (DEXA). Results The age, monocyte, and MHR in the osteoporosis group were significantly higher than those in the normal group and the osteopenia group (P<0.05). The height, LDL-C, and UA in the osteoporosis group decreased significantly (P<0.05). The results of Pearson correlation analysis showed that there was a negative correlation between MHR and BMD in T2DM patients. Multiple logistic regression analysis showed that age, female gender, MHR, and TC were independent risk factors of osteoporosis in elderly patients with type 2 diabetes mellitus. According to ROC curve, the AUC area and cut off value of MHR were 0.728 and 0.338, respectively, and the specificity and sensitivity were 0.750 and 0.656 (95% CI: 0.664-0.793), respectively. Conclusion The level of serum MHR in elderly patients with type 2 diabetes mellitus and osteoporosis can be used as the diagnosis predicting index, and it provides the guidance for clinical practice. |