| Objective To evaluate the correlation between serum prolactin levels and bone metabolism indexes and bone mineral density (BMD) in postmenopausal women. Methods One hundred and sixty-one healthy postmenopausal women participated in this cross-sectional study. Fasting venous blood samples were obtained for the evaluation of bone metabolism indicators and hormone levels. Anthropometric parameters included body mass index (BMI) and waist-to-hip ratio (WHR). DXA was used to detect BMD at the femoral neck (FN) and lumbar spine (LS). Results A total of 161 postmenopausal women were included in this study. The average age was 59.7 ± 6.1 years, the average menopause time was 8.0 ± 1.3 years, and the serum prolactin was 54.98 ± 6.15 μg/L. Spearman correlation analysis showed that the ovary volume was positively correlated with age, YSM, FSH, PTH, LH, OC, and CTX, but was negatively correlated with BMI, LS BMD, FN BMD, estradiol, testosterone, and 25-hydroxyvitamin D, and was not related to other mixed factors. Multiple regression analysis showed that age, BMI, YSM, LS BMD, FN BMD, FSH, LH, estradiol, OC and CTX were independent predictors of prolactin elevation in postmenopausal women. Conclusion Elevation of prolactin in postmenopausal women is closely associated with reduced estrogen levels, decreased BMD, and accelerated bone turnover. |