| Objective To explore the association between adipocytokines and postmenopausal osteoporosis (PMOP) with systematical evaluation. Methods The case-control studies and the cohort studies about the association between adipocytokines (leptin, adiponectin, and resistin) and PMOP were retrieved from CNKI, CBM, Chinese Science and Technique Journals Database, Wanfang database, the Cochrane Library, PubMed, Web of Science, and EMBASE during the time from the establishment of database to 30 January 2020. The quality was assessed according to the Newcastle Ottawa Scale. The information and data of research were accurately extracted. System evaluation, meta-analysis, and funnel plots were conducted with a RevMan 5.3 software. Results A total of 14 case control studies were involved, including 1094 individuals. Among them, 615 were in PMOP group and 479 were in control group. Meta-analysis results showed that: leptin (MD= -1.58, 95% CI: -3.05 to -0.11, P=0.03) in PMOP group was lower than that in the control group, and adiponectin (MD=3.41, 95% CI: 0.84 to 5.99, P=0.009) and resistin (MD=0.73, 95% CI: 0.24 to 1.21, P=0.003) were higher than those in the control group. Conclusion Postmenopausal women with low leptin, high adiponectin, or high adiponectin are more likely to suffer from osteoporosis. Low leptin and high adiponectin reflect a decrease in BMI. It is suggested that the incidence of PMOP may be negatively correlated with BMI in postmenopausal women. |