中国骨质疏松杂志

影响绝经后女性腰椎骨密度的相关因素研究

Factors associated with bone mineral density of the lumbar spine in postmenopausal women

DOI：10.3969/j.issn.1006-7108.2020.11.017

英文关键词:lumbar vertebrae bone mineral density osteocalcin chronic obstructive pulmonary disease women menopause

基金项目:浙江省医药卫生平台重点资助计划项目（2016ZDA002）

作者	单位
张晨阳1 边平达1，2* 李秀央3	1.青岛大学医学部，山东青岛 266021 2.浙江省人民医院/青岛大学附属人民医院老年医学科，浙江杭州 310024 3.浙江大学流行病与卫生统计学系，浙江杭州 310058

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中文摘要:

目的寻找绝经后女性腰椎骨密度（lumbar spine bone mineral density，LSBMD）的独立相关因素。方法调查212例绝经后女性的伴随疾病，并检测LSBMD、骨代谢、血生化和性激素等指标，筛选绝经后女性LSBMD的独立相关因素。结果绝经后女性LSBMD的独立相关因素包括骨钙素(β=-0.003，P＜0.01)、体质量指数(β=0.021，P＜0.01)、慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）(β=-0.153，P＜0.01)和尿酸(β=0.001，P＜0.05)。结论积极防治COPD，降低血清骨钙素水平，维持合理的尿酸和体质量指数，可能是提高绝经后女性LSBMD的有效方法。

英文摘要:

Objective To investigate factors associated with lumbar spine bone mineral density (LSBMD) in postmenopausal women. Methods A total of 212 postmenopausal women were included in the study. Their concomitant diseases, LSBMD, bone metabolism, blood biochemistry, and sex hormones were collected and analyzed for independent factors associated with LSBMD in postmenopausal women. Results It was found that serum osteocalcin (β=-0.003, P＜0.01) , body mass index (BMI, β=0.021, P<0.01), chronic obstructive pulmonary disease (COPD, β=-0.153, P<0.01), and serum uric acid (β=0.001, P<0.05) were independent factors associated with LSBMD in postmenopausal women. Conclusion Strategies including active prevention and treatment of COPD, the reduction of serum osteocalcin level, and the maintenance of reasonable uric acid and BMI may be effective to improve LSBMD in postmenopausal women.

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