| Sarcopenia is an age-related senile syndrome of decreased muscle strength and limited physical function. There is an increased risk of adverse consequences such as falls, physical disabilities, hospitalization, and premature death in the elderly. Prolonged life expectancy leads to aging, and the incidence and prevalence of sarcopenia increased significantly. In 2016, the International Health Organization included it in the Tenth Revision of the International Classification of Diseases: Clinical Modification (ICD-10-CM), with the disease code being M62.84[1]. The current most commonly used definition of sarcopenia is proposed by the European Working Group on Sarcopenia of the Elderly (EWGSOP), which means progressive body mass loss, and muscle strength decline or muscle dysfunction related to aging. In 2019, EWGSOP updated the definition of sarcopenia. Sarcopenia is considered to be a relevant determinant of negative health outcomes in old age. Loss of muscle strength and mobility leads to physical balance disorders. The rate of falls and fractures in the elderly increases, thus increasing the rate of social disability and the national medical burden. It is very important to clarify the etiology of the disease. In recent years, scholars at home and abroad have found that sarcopenia is related to exercise factors, endocrine factors, chronic inflammation, nutritional status, intestinal flora, genetic factors, and psychosocial factors. However, the specific etiology is not clear yet. In this paper, by reviewing a large number of relevant literature, the current status and progress of the etiology of sarcopenia is reviewed. |