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| 骨质疏松症发病相关长链非编码RNA的研究进展 |
| Advances in the study of long non-coding RNA associated with osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2020.11.028 |
| 中文关键词: 骨质疏松 基因 代谢组 lncRNAs mRNAs |
| 英文关键词:osteoporosis gene metabolic group lncRNAs mRNAs |
| 基金项目:北京市卫生系统高层次卫生技术人才培养计划（2015-3-009） |
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| 中文摘要: |
| 非编码RNA如长链非编码RNA（long non-coding RNA，lncRNA）可以在转录、转录后和表观遗传学水平上调节目标基因，目前发现其与mRNA、miRNA、蛋白均存在互作机制，包括骨质疏松在内的多种疾病中都有lncRNA调控涉及。本文基于目前lncRNA在骨质疏松方面的研究现状，总结了当前的研究热点，并对未来的发展趋势进行展望。 |
| 英文摘要: |
| Non-coding RNA such as long non-coding RNA (lncRNA) can regulate target genes at the transcriptional, post-transcriptional, and epigenetic levels. Currently, it has been found that mRNA, miRNA, and proteins interact with each other, and lncRNA regulation is involved in a variety of diseases including osteoporosis. Based on the current research status of lncRNA in osteoporosis, this paper summarizes the current research hotspots and forecasts the future development trend. |
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