| Objective To explore the correlation between serum interleukin-33 (IL-33) and bone mineral density and bone metabolism indexes in postmenopausal women with osteoporosis. Methods In 50 postmenopausal osteoporotic patients and 50 healthy postmenopausal control women, serum IL-33 levels were measured using enzyme linked immunosorbent assay. In both patients and controls, bone mineral density (BMD) was measured usingduel-energy X-ray absorptiometry (DXA). Serum levels of vitamin D, calcium, alkaline phosphatase (ALP), parathyroid hormone (PTH) , as well as bone turnover markers, such as C-terminal telopeptide of type 1 collagen (CTX) and N-terminal propeptide of type 1 procollagen (P1NP) were also detected. Results In postmenopausal women with osteoporosis, the level of IL-33 was significantly lower than that in the healthy control group (3.53 ± 2.45 vs 13.72 ± 5.39 pg/mL; P=0.007). Spearman correlation analysis showed that serum IL-33 levels were negatively correlated to age, BMI, PTH, CTX, and P1NP, but were positively correlated with BMD of the lumbar vertebrae and femoral neck. Multiple regression analysis showed that age, BMI, lumbar BMD, PTH, femoral neck BMD, and serum CTX and P1NP levels were independent predictors of decreased serum IL-33 levels in patients with osteoporosis. Conclusion Decreased serum IL-33 is a risk factor for the reduction of BMD and the increase of bone turnover in femoral neck and lumbar vertebrae in postmenopausal osteoporosis patients. |