| Glucocorticoid osteoporosis (GIOP) is caused by long-term or excessive use of glucocorticoids, which affects the process of bone reconstruction. This paper summarizes the research progress of GIOP from the physiological and pathological functions of glucocorticoids, as well as its dynamic changes. It is found that the imbalance of yin and Yang caused by glucocorticoids was the root cause of the onset of GIOP. The key of pathological changes is kidney. The imbalance of kidney yin and Yang is the core of pathogenesis development and transformation, which shows the evolution law of "deficiency of kidney yin - deficiency of Kidney Yang - deficiency of kidney yin and Yang". The keys of GIOP are three: deficiency of internal Zang-Fu, stagnation of Qi and blood, loss of nourishment of bones. Stage and compound are emphasized throughout this process. According to the research above, the treatment method of "regulating yin and Yang horizontally" is established. On the one hand, we emphasize that regulating yin and Yang horizontally must be a dynamic balance process. On the other hand, to achieve the balance of yin and Yang of the whole body at the same time of regulating kidney yin and Yang horizontally, and regulate the Yin and Yang of the primary disease. Finally, the balance of yin and Yang, the circulation of qi and blood, the nourishment of muscles and bones are achieved. It has been confirmed that autophagy is the micro mechanism of the dynamic balance of yin and Yang, and it is also the target of "regulating yin and Yang equally" to improve the prevention and treatment of GIOP. Therefore, regulating yin and Yang is an important way to prevent and treat GIOP. |