| Objective To provide evidence of the effect of traditional Chinese medicine (TCM) on postmenopausal osteoporosis (PMOP), based on theory of yin deficiency of the liver and kidney. Methods Literature of randomized controlled clinical trials on the effect of TCM based on method of regulating liver and kidney in treatment of PMOP was retrieved from CNKI, China biomedical database, Chinese Science and Technique Journals Database, Wan Fang database, the Cochrane Library, PubMed, and EMBASE. The retrieval time was from database establishment to September 2019. System evaluation and meta-analysis were performed with a RevMan 5.3 software. Results Nine references were included, including a total of 9 researches. Compared with conventional therapy with Chinese patent medicine or western medicine, the treatment based on theory of regulating liver and kidney reduced TCM syndrome score (MD=-3.74, 95%CI -4.86, -2.62, P<0.01; MD=-2.05, 95%CI -2.26, -1.84, P<0.01) and improved serum estrogen (SMD=0.69, 95%CI 0.21, 1.17, P<0.01; SMD=0.37, 95%CI 0.01, 0.74, P=0.04). The clinical efficiency of the use of regulating the liver and kidney method was better than conventional treatment (RR=1.03, 95% CI 0.90, 1.17, P=0.68; RR=1.24, 95% CI 0.94, 1.63, P=0.13). Compared with the conventional treatment group, the difference was not statistically significant in improving bone mineral density of lumbar spine and biochemical indicators in blood. There was no adverse reactions in included studies using TCM based treatment alone or combination treatment. Conclusion Chinese patent medicine and decoction based on the theory of regulating liver and kidney have certain therapeutic effect on relieving the symptoms of pain and weakness of waist and spinal, improving serum level of estrogen in PMOP patients with yin deficiency of the liver and kidney, with good security. |