| Objective To explore the relationship between type 2 diabetes mellitus with peripheral neuropathy and bone metabolism indexes β-CTX and PINP. Methods One hundred and eighty-nine patients with type 2 diabetes from October 2017 to August 2018 in the Department of Endocrinology, the Affiliated Hospital of Zunyi Medical University, were selected. They were divided into diabetes with peripheral neuropathy group (DPN group, n=97) and diabetes without neuropathy group (NDPN group, n=92) according to whether they had peripheral neuropathy or not. The levels of FPG, HbA1c, C peptide, TG, TC, LDL-C, HDL-C, Ca, P, BMD (L2-L4, Neck, Troch, and Ward triangle), β-CTX, and PINP were measured. Results Compared with the NDPN group, levels of FPG, HbA1c, FIns, HOMA-IR, and TG were higher, but P, HDL-C, lumbar spine L2-L4, femoral Neck, and Troch BMD, β-CTX, and PINP were lower in the DPN group (P<0.05). Pearson correlation analysis showed that β-CTX was negatively correlated with FPG (r=0.484, P<0.05), and PINP was positively correlated with HDLC and P (r=0.242, 0.309, P<0.05) and negatively correlated with HbA1c, HOMA-IR and femoral neck Neck (P<0.05). Conclusion The serum levels of β-CTX and PINP are reduced, bone turnover is abnormal, and the risk of fracture is higher in DPN patients . |