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| 新疆绝经后2型糖尿病女性SOST蛋白表达在骨质疏松中诊断价值的研究 |
| The value of SOST protein for the diagnosis of osteoporosis in postmenopausal women with type 2 diabetes |
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| DOI：10.3969/j.issn.1006-7108.2021.01.006 |
| 中文关键词: SOST蛋白 2型糖尿病 骨质疏松 骨密度 绝经后女性 |
| 英文关键词:SOST protein diabetes mellitus type 2 osteoporosis bone mineral density postmenopausal women |
| 基金项目:区域创新引导计划（2018BB040）；石河子大学成果转化与技术推广项目（CGZH201911） |
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| 中文摘要: |
| 目的 探讨SOST蛋白表达水平与骨代谢的关系及其在骨质疏松（osteoporosis，OP）中的诊断价值，为预防绝经后2型糖尿病（type 2 diabetes mellitus，T2DM）女性合并OP的发生提供依据。方法 纳入对象为135例新疆绝经后女性，记录其年龄等一般基线资料；全自动生化分析仪测定空腹血糖（FPG）、碱性磷酸酶(ALP)等生化指标；双能X线吸收检测法(dual energy X-ray absorptiometry，DXA)测定股骨颈及腰椎（L1～4）骨密度（BMD）；酶联免疫吸附法（ELISA）测定SOST蛋白的表达水平。结果 （1）与A组（277.261±251.144）相比，B组（785.507±366.941）和D组（884.056±631.041）的SOST蛋白表达水平高于A组，差异具有统计学意义(P＜0.01)。（2）通过绘制ROC曲线显示，SOST蛋白表达水平诊断OP的最佳临界点为0.479 pg/mL，敏感度为61.4%，特异性为86.5%，曲线下面积（AUC）为0.741（95%可信区间：0.656～0.827）；（3）Pearson相关性分析显示，新疆绝经后T2DM女性SOST蛋白表达水平与BMD（L1～4）呈负相关（r=-0.239，P=0.005）。结论 （1）新疆绝经后T2DM女性SOST蛋白表达水平与骨代谢有关，且SOST蛋白高表达是腰椎BMD（L1～4）降低的危险因素。（2）以SOST蛋白表达水平≥47.9%为0P的诊断标准，有较大的AUC和更高的敏感性。 |
| 英文摘要: |
| Objective To explore the expression of SOST protein for the diagnosis of osteoporosis and to analyse the relationship between the expression of SOST protein and bone mineral density (BMD) and bone metabolism markers in postmenopausal women with type-2 diabetes mellitus (T2DM), and to provide a basis for prevention and treatment of the disease. Methods A total of 135 postmenopausal women were included in the study. The data at the baseline were collected. The clinical biochemical data such as fasting plasma glucose (FPG) and alkaline phosphatase (ALP) were determined. BMD of the femoral neck and lumbar spine (L1-4) was measured using dual energy X-ray (DEXA). The expression level of SOST protein was determine with enzyme-linked immunosorbent assay (ELISA). Results (1) The expression level of SOST protein was higher in group B (785.507±366.941) and group D (884.056±631.041) than that in group A (277.261±251.144), and the difference was statistically significant (P<0.01). (2) According to ROC curve, the optimal critical point for SOST protein expression level to diagnose OP was 0.479 pg/ml. The sensitivity was 61.4%, the specificity was 86.5%, and the area under the curve (AUC) was 0.741 (95% confidence interval: 0.656 - 0.827). (3) Pearson correlation analysis showed that the expression level of SOST protein was negatively correlated with BMD (L1-4) in postmenopausal T2DM women in Xinjiang (r=-0.239, P=0.005). Conclusion (1) The expression of SOST protein may be related to bone metabolism and the high expression of SOST protein is a risk factor for reduced lumbar BMD (L1-4) in postmenopausal women with type 2 diabetes in Xinjiang. (2) The expression level of SOST protein ≥47.9% as the diagnostic criterion of OP exists a larger AUC and higher sensitivity. |
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