| Objective To study the association between hemoglobin (Hb) and osteoporosis in elder patients with type 2 diabetes mellitus (T2DM). Methods A total of 498 elder people with T2DM who admitted to the Department of Endocrinology, Xuanwu Hospital of Capital Medical University were included in the study. The participants were divided into osteoporosis group (n=160) and non-osteoporosis group (n=338) according to the measurement of the bone mineral density. The levels of Hb, fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c), 25-hydroxyvitamin D3 (25-OHD3), interleukin-6 (IL-6), and C-reactive protein (CRP) were measured. Results The body mass index (BMI), 25-OHD3, estimated glomerular filtration rate (eGFR), and Hb levels in the osteoporosis group were significantly lower than those in the non-osteoporosis group (P<0.001), but age was much higher in the osteoporosis group (P=0.017). The prevalence of anemia was significantly higher in the osteoporosis group (25.00% vs 16.57%, P=0.026). Multivariate logistic regression analysis showed that female, BMI, and Hb levels were independent influencing factors for osteoporosis (OR=3.10, P<0.001; OR=0.86, P<0.001; OR=0.90, P=0.018, respectively). Conclusion Hb levels are significantly associated with the occurrence of osteoporosis in elder adults with T2DM. |