| Objective To investigate the relationship between serum neuropeptide Y (NPY) level and bone mineral density (BMD) in postmenopausal women. Methods This study included postmenopausal women who were treated in the outpatient clinic of our hospital. Serum calcium, phosphorus, albumin, parathyroid hormone (parathyroid hormone,PTH), thyroid stimulating hormone (thyrotropin, TSH), 25-OH vitamin D, and NPY were measured. According to the results of bone mineral density, the subjects were divided into three groups: normal BMD (n=66), osteopenia (n=63), and osteoporosis (n=63). According to the serum NPY level, the subjects were also divided into three groups: low NPY (n=30), normal NPY (n=126), and high NPY (n=36). Results There were significant differences in serum NPY, PTH, and age in patients with normal BMD, osteopenia, or osteoporosis. For different NPY levels, there were significant differences in BMD of the lumbar vertebrae, total femur, femoral neck, trochanter, intertrochanteric, and Ward triangle among groups. Correlation analysis showed that the level of serum NPY was positively correlated with age and BMI, and was negatively correlated with BMD in different parts of the patients (P<0.05). Conclusion There is correlation between serum NPY levels and age, body mass index, and any measured BMD values in the patients. |