| Objective To analyze bone metabolism characteristics and risk factors of bone loss in middle aged and elderly patients with type 2 diabetes mellitus (T2DM). Methods Six hundred and twelve T2DM patients were divided into 3 groups according to bone mineral density (BMD) level, normal group (108 cases), osteopenia group (281 cases), and osteoporosis group (223 cases). The differences among the groups were analyzed. Results In females, age and the levels of parathyroid hormone (PTH), procollagen type I N-propeptide (PINP), and collagen type I cross-linked C-telopeptide (CTX) were significantly higher, but body mass index (BMI), uric acid (UA), and 25-hydroxy vitamin D [25(OH)D] were significantly lower in osteoporosis group. BMD of the lumbar spine1-4 was positively correlated to BMI, UA, and 25(OH)D, but negatively correlated to age, PTH, PINP and CTX. In males, PTH was significantly higher but BMI was significantly lower in osteoporosis group. BMD of the lumbar spine1-4 was positively correlated to BMI and UA but negatively correlated to PTH. Ordinal logistic regression results showed that age, high level of PTH or PINP, low levels of BMI, UA, or 25(OH)D were risk factors of osteoporosis in females. High level of PTH and low level of BMI were risk factors of osteoporosis in males. Conclusion Bone turnover level increases in female osteoporosis patients with type 2 diabetics but it has no significant change in males. However, low BMI and high PTH level are associated with the development of osteoporosis in both female and male patients. |